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Titolo:
An admonition when measuring the lipophilicity of radiotracers using counting techniques
Autore:
Wilson, AA; Jin, L; Garcia, A; DaSilva, JN; Houle, S;
Indirizzi:
Ctr Addict & Mental Hlth, Vivian M Rackoff PET Ctr, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5T 1R8 to, ON M5T 1R8, Canada
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 2, volume: 54, anno: 2001,
pagine: 203 - 208
SICI:
0969-8043(200102)54:2<203:AAWMTL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Keywords:
lipophilicity; log P; QSAR; radiotracers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, AA Ctr Addict & Mental Hlth, Vivian M Rackoff PET Ctr, 250 Coll St, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth 250 Coll St Toronto ON Canada M5T 1R8
Citazione:
A.A. Wilson et al., "An admonition when measuring the lipophilicity of radiotracers using counting techniques", APPL RAD IS, 54(2), 2001, pp. 203-208

Abstract

Log P measurements are a fundamental physico-chemical parameter and one ofthe cornerstones of structure-activity relationships in medicinal chemistry. Despite the attractiveness of the method, the use of counting techniquesto measure the log P of lipophilic radiotracers is fraught with pitfalls due to the amplifying effects of small quantities of radioactive impurities. For example, a radiotracer with a log P of 4 containing only 0.1% of a radioactive impurity with a log P of -1 will have an apparent log P of 3 if measured using conventional shake-flask partition techniques, counting the radioactivity in each phase. However, pre-washing the radiotracer-containing organic phase with aqueous phase can, in many cases, allay doubts about thevalidity of such measurements. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:48:46