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Titolo:
Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients - The influence of cardiac output
Autore:
Kuipers, JA; Boer, F; Olofsen, E; Bovill, JG; Burm, AGL;
Indirizzi:
Leiden Univ, Med Ctr, Dept Anesthesiol P5, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 1, volume: 94, anno: 2001,
pagine: 47 - 55
SICI:
0003-3022(200101)94:1<47:RPAPOR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADDUCTOR POLLICIS; PULMONARY UPTAKE; BLOOD; MODEL; PROPOFOL; DOGS; ELIMINATION; ARTERIAL; KINETICS; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Burm, AGL Leiden Univ, Med Ctr, Dept Anesthesiol P5, POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ POB 9600 Leiden Netherlands NL-2300 RC Netherlands
Citazione:
J.A. Kuipers et al., "Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients - The influence of cardiac output", ANESTHESIOL, 94(1), 2001, pp. 47-55

Abstract

Background: Recirculatory models are capable of accurately describing first-pass pharmacokinetics and the influence of cardiac output (CO), which is important for drugs with a fast onset of effect. The influence of CO on pharmacokinetic and pharmacodynamic parameters of rocuronium in patients was evaluated using a recirculatory pharmacokinetic model. Methods: Fifteen patients were included to study rocuronium pharmacokinetics and pharmacodynamics. Bolus doses of rocuronium (0.35 mg/kg) and indocyanine green (25 mg) were injected simultaneously via a peripheral intravenous catheter. Blood samples were taken for 240 min from the radial artery. The force of contraction of the adductor pollicis after a train-of-four at 2 Hz every 12 s was measured. Arterial concentration-time curves of rocuronium and indocyanine green were analyzed using a recirculatory model. Pharmacodynamics were described using a sigmoid maximum effect (E-max) model. Results: The CO of the patients varied from 2.43 to 5.59 1/min. Total distribution volume of rocuronium was 17.3 +/- 4.8 1 (mean +/- SD). The CO showed a correlation with the fast tissue clearance (ClT-f; r(2) = 0.51), with the slow tissue clearance (ClT-s; r(2) = 0.31) and with the mean transit times of rocuronium except for the mean transit time of the slow tissue compartment. The blood-effect site equilibration constant (k(e0)) was strongly correlated with CO (r(2) = 0.70). Conclusions: Cardiac output influences the pharmacokinetics, including k(e0), for rocuronium in patients. For drugs with a fast onset of effect, a recirculatory model, which includes CO, can give a good description of the relation between concentration and effect, in contrast to a conventional compartmental pharmacokinetic model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:01:50