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Titolo:
Intramuscular rapacuronium in infants and children - A comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects
Autore:
Denman, WT; Kaplan, RF; Goudsouzian, NG; Uejima, T; Barcelona, SL; Cote, CJ; Ginsberg, B; Hannallah, RS;
Indirizzi:
Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 rit Care, Boston, MA 02114 USA Childrens Natl Med Ctr, Dept Anesthesiol, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 , Washington, DC 20010 USA Childrens Mem Hosp, Dept Anesthesiol, Chicago, IL 60614 USA Childrens Mem Hosp Chicago IL USA 60614 nesthesiol, Chicago, IL 60614 USA Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Ctr, Dept Anesthesiol, Durham, NC 27710 USA Childrens Natl Med Ctr, Dept Pediat, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 , Washington, DC 20010 USA Childrens Mem Hosp, Dept Pediat, Chicago, IL 60614 USA Childrens Mem HospChicago IL USA 60614 ept Pediat, Chicago, IL 60614 USA
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 1, volume: 94, anno: 2001,
pagine: 3 - 7
SICI:
0003-3022(200101)94:1<3:IRIIAC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROMUSCULAR BLOCKADE; ADDUCTOR POLLICIS; SUCCINYLCHOLINE; ANESTHESIA; ROCURONIUM; SEVOFLURANE; HALOTHANE; INDUCTION; ORG-9487; MUSCLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Denman, WT New England Med Ctr, Dept Anesthesia, 750 Washington St,Box 298, Boston, MA 02111 USA New England Med Ctr 750 Washington St,Box 298 BostonMA USA 02111
Citazione:
W.T. Denman et al., "Intramuscular rapacuronium in infants and children - A comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects", ANESTHESIOL, 94(1), 2001, pp. 3-7

Abstract

Background: This multicenter, assessor, blinded, randomized study was conducted to confirm and extend a pilot study in which intramuscular rapacuronium was given to infants and children to confirm efficacy and to evaluate tracheal intubating conditions. Methods: Ninety-six pediatric patients were studied in two groups: infantsaged 1 to 12 months (n = 46) and children aged 1 to 3 yr (n = 50). Infantsreceived 2.8 mg/kg and children 4.8 mg/kg of intramuscular rapacuronium during 1 minimum alveolar concentration halothane anesthesia. These two groups were studied in three subgroups, depending on the time (1.5, 3, or 4 min)at which tracheal intubation was attempted after the administration of intramuscular rapacuronium into the deltoid muscle. Neuromuscular data collected included onset time, duration of action, and recovery data during train-of-four stimulation at 0.1 Hz. Data were analyzed by the Cochran-Mantel-Haenszel procedure. Results: The tracheal intubating conditions were deemed acceptable in 17, 36, and 64% of infants and 20, 47, and 71% of children at 1.5, 3, or 4 min,respectively. The mean values for % of control twitch height (T1) 2 min after rapacuronium in both groups were similar. The mean (SD) time required to achieve more than or equal to 95% twitch depression in infants was 6.0 (3.7) versus 5.5 (3.8) min in children. Conclusions: Only 27% of patients achieved clinically acceptable tracheal intubating conditions at 1.5 or 3 min after administration of 2.8 mg/kg and4.8 mg/kg rapacuronium during 1 minimum alveolar concentration halothane anesthesia. Tracheal intubation conditions at 4 min were acceptable in 69% of subjects. The duration of action of 4.8 mg/kg of rapacuronium in childrenwas longer than 2.8 mg/kg of rapacuronium in infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 10:24:05