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Titolo:
Pituitary adenylate cyclase activating peptide (PACAP) in the enteropancreatic innervation
Autore:
Kirchgessner, AL; Liu, MT;
Indirizzi:
SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Brooklyn NY USA 11203 Pharmacol, Brooklyn, NY 11203 USA
Titolo Testata:
ANATOMICAL RECORD
fascicolo: 1, volume: 262, anno: 2001,
pagine: 91 - 100
SICI:
0003-276X(20010101)262:1<91:PACAP(>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; INFERIOR MESENTERIC GANGLION; ENTERIC NERVOUS-SYSTEM; GUINEA-PIG ILEUM; POLYPEPTIDE PACAP; MOLECULAR-CLONING; ULTRASTRUCTURAL-LOCALIZATION; GASTROINTESTINAL-TRACT; TISSUE DISTRIBUTION; TRANSMITTER CONTENT;
Keywords:
pancreatic ganglia; enteric ganglia; PAC1 receptor; vasoactive intestinal peptide; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kirchgessner, AL SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Box 29,450 Clarkson Ave, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Box 29,450 Clarkson Ave Brooklyn NY USA 11203
Citazione:
A.L. Kirchgessner e M.T. Liu, "Pituitary adenylate cyclase activating peptide (PACAP) in the enteropancreatic innervation", ANAT REC, 262(1), 2001, pp. 91-100

Abstract

Pancreatic ganglia are innervated by neurons in the gut and are formed by precursor cells that migrate into the pancreas from the bowel. The innervation of the pancreas, therefore, may be considered an extension of the enteric nervous system. Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in a subset of enteric neurons. We investigated the presence of PACAP in the enteropancreatic innervation in guinea pigs, and the response of pancreatic neurons to PACAP-related peptides. PACAP immunoreactivity was found in nerve fibers in both enteric and pancreatic ganglia and in nerve bundles that travelled between the duodenum and pancreas. PACAP-immunoreactive nerve fibers were densely distributed in the pancreatic ganglia, where they surrounded a subset of cholinergic cell bodies. Pancreatic ganglia did not contain PACAP-immunoreactive cell bodies; however, neuronal perikarya with PACAP immunoreactivity were found in the myenteric plexus of the duodenum. These cells co-stored vasoactive intestinal peptide (VIP). PACAP depolarized pancreatic neurons. Pancreatic neurons were also depolarized by VIP; however, PACAP was more efficacious at depolarizing pancreatic cells than VIP. These findings are consistent with the view that the PACAP effects were mediated through PACAP-selective (PAC1) receptors. PACAP-responsive neurons displayed PAC1 receptor immunoreactivity, which was also found in islet cells and enteric neurons. These results provide support for the hypothesis that PACAP modulates reflex activity between the gut and pancreas. The excitatory effect of PACAP would be expected to potentiate pancreatic secretion. Anat Rec 262:91-100, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:14:41