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Titolo:
Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis
Autore:
Brewer, WJ; Pantelis, C; Anderson, V; Velakoulis, D; Singh, B; Copolov, DL; McGorry, PD;
Indirizzi:
Mental Hlth Res Inst, Cognit Neuropsychiat Res & Acad Unit, Appl Schizophrenia Div, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 le, Vic 3052, Australia Univ Melbourne, Cognit Neuropsychiat Res & Acad Unit, Parkville, Vic 3052,Australia Univ Melbourne Parkville Vic Australia 3052 Parkville, Vic 3052,Australia Mental Hlth Serv Kids & Youth, Early Psychosis Prevent & Intervent Ctr, Parkville, Vic, Australia Mental Hlth Serv Kids & Youth Parkville Vic Australia le, Vic, Australia Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Univ Melbourne, Dept Psychol, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 158, anno: 2001,
pagine: 107 - 115
SICI:
0002-953X(200101)158:1<107:SOOIDI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARK MULTIDIAGNOSTIC INSTRUMENT; ADULT READING TEST; CHRONIC-SCHIZOPHRENIA; SEX-DIFFERENCES; PERFORMANCE; ABILITY; DYSFUNCTION; DEPRESSION; DISORDERS; DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Brewer, WJ Mental Hlth Res Inst, Cognit Neuropsychiat Res & Acad Unit, Appl Schizophrenia Div, 155 Oak St,Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst 155 Oak St,Locked Bag 11 Parkville Vic Australia 3052
Citazione:
W.J. Brewer et al., "Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis", AM J PSYCHI, 158(1), 2001, pp. 107-115

Abstract

Objective: Olfactory identification deficits and their relationship to negative symptoms in patients with schizophrenia were examined in patients with recent-onset psychosis, the majority of whom were neuroleptic naive. Method: Seventy-four inpatients with a first episode of psychosis (27 withschizophrenia or schizophreniform disorder, nine with schizoaffective disorder, 17 with affective psychoses, and 21 with other psychoses), 49 of whomhad not received antipsychotic medication, were compared to 38 age- and gender-matched normal subjects. Olfactory identification ability was assessedwith the University of Pennsylvania Smell Identification Test. Forty patients and 13 comparison subjects were reassessed at 6 months to examine whether olfactory deficits were specific to schizophrenia or schizophreniform disorder and were stable over time. Results: At baseline, the patients had significant impairment in olfactoryidentification ability compared to the normal subjects. This difference persisted after controlling for gender, premorbid or current IQ, smoking history, cannabis use, or the effects of medication. Diagnostic subgroups did not differ in olfactory identification ability. The deficits remained stableat 6-month follow-up and were associated with negative symptoms at both time points. No relationship was found between olfactory identification ability and length of either untreated psychosis or illness prodrome. Conclusions: Impairment in olfactory identification ability was apparent from the outset of psychotic illness and was not specific to schizophrenia or schizophreniform disorder. No change in the degree of this deficit was found after patients were stabilized and had responded to medication. The deficit could not be explained by peripheral factors that might contribute to olfactory identification ability, suggesting that it reflects central mechanisms.

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Documento generato il 20/01/20 alle ore 16:06:00