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Titolo:
Functional imaging studies: Linking mind and basic neuroscience
Autore:
Shulman, RG;
Indirizzi:
Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ophys & Biochem, New Haven, CT 06520 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 158, anno: 2001,
pagine: 11 - 20
SICI:
0002-953X(200101)158:1<11:FISLMA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATERGIC NEURONAL-ACTIVITY; POSITRON-EMISSION-TOMOGRAPHY; C-13 NMR-SPECTROSCOPY; CEREBRAL BLOOD-FLOW; RAT-BRAIN INVIVO; IN-VIVO C-13-NMR; GLUCOSE-UTILIZATION; OXYGEN-CONSUMPTION; VISUAL-CORTEX; METABOLISM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Shulman, RG Yale Univ, Sch Med, Dept Mol Biophys & Biochem, POB 208024, New Haven, CT 06520 USA Yale Univ POB 208024 New Haven CT USA 06520 aven, CT 06520 USA
Citazione:
R.G. Shulman, "Functional imaging studies: Linking mind and basic neuroscience", AM J PSYCHI, 158(1), 2001, pp. 11-20

Abstract

objective: The imaging of brain activity with positron emission tomography(PET) and functional magnetic resonance imaging has assumed a central position in psychiatry. Functional imaging signals arise from changes in the neurophysiological parameters of glucose and oxygen consumption mediated by blood flow. Method: Recent in vivo C-13 nuclear magnetic resonance (NMR) neurochemicalstudies have established a quantitative coupling between the rates of glucose oxidation and glutamate neurotransmitter flux in rats and humans, thereby linking measured neurophysiological parameters to brain function. Results: These results show that in the awake, resting, and unstimulated slates, 70%-80% of brain energy consumption is devoted to the same glutamate/glutamine neurotransmitter signaling as are the small percentages stimulated by tasks. Furthermore, in anesthetized animals, in which unstimulated activity is reduced, the total signal rather than a particular increment is required for a response. Conclusions: On this basis, the total signal, as well as the difference inthe signal, measures cortical neurotransmitter flux. The total signal in aregion therefore contains valuable information about required brain activity Although signal change is often more easily measured, certain PET and C-13 NMR methods can quantify total regional signal activity and thereby provide another measure of neurotransmitter activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:21:22