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Titolo:
Linkage studies suggest a possible locus for developmental dyslexia on chromosome 1p
Autore:
Grigorenko, EL; Wood, FB; Meyer, MS; Pauls, JED; Hart, LA; Pauls, DL;
Indirizzi:
Yale Univ, Sch Med, Dept Psychol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 d, Dept Psychol, New Haven, CT 06520 USA Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Ctr Child Study, New Haven, CT 06520 USA Moscow State Univ, Dept Psychol, Moscow, Russia Moscow State Univ MoscowRussia tate Univ, Dept Psychol, Moscow, Russia Bowman Gray Sch Med, Dept Neurol, Sect Neuropsychol, Winston Salem, NC USABowman Gray Sch Med Winston Salem NC USA opsychol, Winston Salem, NC USA Univ Vermont, Dept Biochem, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 pt Biochem, Burlington, VT 05405 USA Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Psychol, Pittsburgh, PA 15260 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 105, anno: 2001,
pagine: 120 - 129
SICI:
0148-7299(20010108)105:1<120:LSSAPL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE-TRAIT LOCUS; READING-DISABILITY; FAMILY DATA; IDENTIFICATION; CHILDREN; DISEASE; SUSCEPTIBILITY; STATISTICS; COMPONENTS; DEFICITS;
Keywords:
developmental dyslexia; linkage; complex phenotype; 1p; Rh;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Grigorenko, EL Yale Univ, Sch Med, Dept Psychol, 2 Hillhouse Ave, New Haven, CT 06520 USA Yale Univ 2 Hillhouse Ave New Haven CT USA 06520 06520 USA
Citazione:
E.L. Grigorenko et al., "Linkage studies suggest a possible locus for developmental dyslexia on chromosome 1p", AM J MED G, 105(1), 2001, pp. 120-129

Abstract

Eight extended dyslexic families with at least four affected individuals were genotyped with twelve genetic markers spanning the Rh (rhesus factor) locus. Eleven of these markers were located on the short arm and the other was on the long arm of chromosome 1. Five theoretically derived phenotypes were used in the linkage analyses: 1) phonemic awareness; 2) phonological decoding; 3) rapid automatized naming; 4) single word reading; and 5) vocabulary. In addition, a lifetime diagnosis of dyslexia was used as a phenotype. Both parametric and non-parametric genetic analyses were completed. The results supported the importance of a putative locus on 1p. In addition, two-locus analyses assuming the interaction between a 1p locus and a 6p locus, previously shown to be of interest for dyslexia, were conducted. As a result, the nonparametric linkage (NPL) scores for rapid automatized naming and phonological decoding were significantly increased. In particular, the NPL scores for rapid automatized naming exceeded 5.0 for certain markers. Theseresults provide strong evidence for separate but jointly acting contributions of the 1p and 6p loci to the reading impairments associated with rapid naming and suggestive evidence for a similar mechanism involving phonological decoding. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 105:120-129, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 04/04/20 alle ore 08:26:23