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Titolo:
Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder
Autore:
Manor, I; Eisenberg, J; Tyano, S; Sever, Y; Cohen, H; Ebstein, RP; Kotler, M;
Indirizzi:
Geha Mental Hlth Ctr, Petak Tikvah, Israel Geha Mental Hlth Ctr Petak Tikvah Israel Hlth Ctr, Petak Tikvah, Israel S Herzog Mem Hosp, Child Psychiat Clin, IL-91351 Jerusalem, Israel S Herzog Mem Hosp Jerusalem Israel IL-91351 , IL-91351 Jerusalem, Israel S Herzog Mem Hosp, Res Lab, IL-91351 Jerusalem, Israel S Herzog Mem Hosp Jerusalem Israel IL-91351 , IL-91351 Jerusalem, Israel Ben Gurion Univ Negev, Fac Hlth Sci, Beersheva Mental Hlth Ctr, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel al Hlth Ctr, Beer Sheva, Israel
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 105, anno: 2001,
pagine: 91 - 95
SICI:
0148-7299(20010108)105:1<91:FASOTS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; GENE REGULATORY REGION; REPEAT LENGTH POLYMORPHISM; BIPOLAR AFFECTIVE-DISORDER; ONSET ALZHEIMERS-DISEASE; FUNCTIONAL POLYMORPHISM; PANIC DISORDER; NO ASSOCIATION; DOPAMINE-D4 RECEPTOR; ALCOHOL DEPENDENCE;
Keywords:
attention deficit hyperactivity disorder (ADHD); serotonin transporter promoter region; 5-HTT; polymorphism; association; haplotype relative risk; complex genetic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Ebstein, RP S Herzog Mem Hosp, Res Lab, POB 35300, IL-91351 Jerusalem, Israel S Herzog Mem Hosp POB 35300 Jerusalem Israel IL-91351 Israel
Citazione:
I. Manor et al., "Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder", AM J MED G, 105(1), 2001, pp. 91-95

Abstract

Low serotonin activity has been associated in both animal and human studies with measures of impulsivity, aggression, and disinhibited behaviors. Recently, a common 44-bp deletion in the promoter region of the serotonin transporter (5-HTTLPR) that results in reduced transcription and lower transporter protein levels was described. Toward unraveling a possible role of the 5-HTTLPR polymorphism in childhood disruptive behaviors, we examined this gene in attention deficit hyperactivity disorder (ADHD), a heterogeneous childhood disorder in which three phenotypes are recognized by DSM IV criteria: inattentive (type I), hyperactive-impulsive (type II), and combined typo (type III). By using the haplotype relative risk design, a group of 98 triads (both parents and proband child) were tested for a possible association between 5-HTTLPR and ADHD. A significant decrease in the short/short 5-HTTLPR genotype was observed in the ADHD type III combined group (10.29% vs. 30.88%) compared with the HRR-derived control group (likelihood ratio = 9.62,P = 0.008, n = 68 triads). Similar results were observed when allele frequencies were compared (likelihood ratio = 3.81, P = 0.05, n = 136 alleles). These first findings should be interpreted cautiously until replicated in independently recruited clinical samples. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 105:91-95, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 08/04/20 alle ore 12:14:53