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Titolo:
Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha 7-nicotinic acetylcholine receptor subunit gene (CHRNA7)
Autore:
Freedman, R; Leonard, S; Gault, JM; Hopkins, J; Cloninger, CR; Kaufmann, CA; Tsuang, MT; Farone, SV; Malaspina, D; Svrakic, DM; Sanders, A; Gejman, P;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Dept Pharmacol, Denver, CO 80262 USA Denver VA Med Ctr, Denver, CO USA Denver VA Med Ctr Denver CO USADenver VA Med Ctr, Denver, CO USA NIMH, Schizophrenia Genet Initiat, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 ophrenia Genet Initiat, Bethesda, MD 20892 USA Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 o, Dept Psychiat, Chicago, IL 60637 USA Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Dept Psychiat, Denver, CO 80262 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 105, anno: 2001,
pagine: 20 - 22
SICI:
0148-7299(20010108)105:1<20:LDFSAT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO EVIDENCE; TDT;
Keywords:
human chromosome pair 15; genetic linkage; nicotinic receptor; polymorphism; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Freedman, R Univ Colorado, Hlth Sci Ctr, Dept Psychiat C268 71, 4200 E 9thAve, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262 CO 80262 USA
Citazione:
R. Freedman et al., "Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha 7-nicotinic acetylcholine receptor subunit gene (CHRNA7)", AM J MED G, 105(1), 2001, pp. 20-22

Abstract

The transmission/disequilibrium test was used for fine mapping of the linkage of schizophrenia to the chromosome 15q13-14 region, the site of a candidate gene, the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7), in parent-child triads from the NIMH Schizophrenia Genetics Initiative families. This candidate gene was identified from neurobiological studies ofdeficits in schizophrenics of the inhibitory gating of the P50 auditory evoked potential. The neurobiological deficit was also used as a phenotype for subsequent linkage analysis. In the present study, significant genotype-wise disequilibrium (P < 0.007) was found at D15S165, a polymorphic simple sequence marker physically located within 1 megabase of both CHRNA7 and a partially duplicated, expressed sequence that includes exons 5-10 of CHRNA7, Replication of this result was found in an additional set of families. The results support this region as a chromosomal location involved in the genetic transmission of schizophrenia. Am. J, Med, Genet, (Neuropsychiatr,Genet,) 105: 20-22, 2001, (C) 2001 Wiley-Liss, Inc.

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Documento generato il 29/03/20 alle ore 14:56:19