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Titolo:
Impaired attention as an endophenotype for molecular genetic studies of schizophrenia
Autore:
Cornblatt, BA; Malhotra, AK;
Indirizzi:
Hillside Hosp, Glen Oaks, NY 11004 USA Hillside Hosp Glen Oaks NY USA 11004 llside Hosp, Glen Oaks, NY 11004 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 105, anno: 2001,
pagine: 11 - 15
SICI:
0148-7299(20010108)105:1<11:IAAAEF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTINUOUS PERFORMANCE-TEST; HIGH-RISK-PROJECT; SUSTAINED ATTENTION; NONPSYCHOTIC RELATIVES; SOCIAL COMPETENCE; BACKWARD-MASKING; EYE TRACKING; SIBLINGS; SYMPTOMS; ADOLESCENTS;
Keywords:
psychosis; risk factors; cognition; phenotype; gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cornblatt, BA Hillside Hosp, 75-59 263rd St, Glen Oaks, NY 11004 USA Hillside Hosp 75-59 263rd St Glen Oaks NY USA 11004 1004 USA
Citazione:
B.A. Cornblatt e A.K. Malhotra, "Impaired attention as an endophenotype for molecular genetic studies of schizophrenia", AM J MED G, 105(1), 2001, pp. 11-15

Abstract

Attentional abnormalities have long been known to characterize patients with schizophrenia. The data discussed in this report suggest that impaired attention (at least as measured by a specific task, the Continuous Performance Test, Identical Pairs (CPT-IP) version) may also be an endophenotype of particular promise for use in molecular genetic studies of schizophrenia. This conclusion is based on findings indicating that the deficits in verbal and spatial attentional processing tapped by the CPT-IP are heritable, developmentally stable, independent of clinical state, and predict future spectrum disorders in the at-risk offspring of parents with schizophrenia. Am. J. Med. Genet, (Neuropsychiatr, Genet,) 105:11-15, 2001, (C) 2001 Wiley-Liss, Inc.

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Documento generato il 23/01/20 alle ore 07:19:24