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Titolo:
Discontinuation of maintenance therapy for cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy
Autore:
Jouan, M; Saves, M; Tubiana, R; Carcelain, G; Cassoux, N; Aubron-Olivier, C; Fillet, AM; Nciri, M; Senechal, B; Chene, G; Tural, C; Lasry, S; Autran, B; Katlama, C;
Indirizzi:
Hop La Pitie Salpetriere, Dept Infect Dis, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 Dis, F-75013 Paris, France Hop La Pitie Salpetriere, Dept Immunol, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 nol, F-75013 Paris, France Hop La Pitie Salpetriere, Dept Ophthalmol, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 mol, F-75013 Paris, France Hop La Pitie Salpetriere, Dept Virol, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 rol, F-75013 Paris, France Hop Louis Pasteur, Paris, France Hop Louis Pasteur Paris FranceHop Louis Pasteur, Paris, France Univ Bordeaux 2, INSERM, U330, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 , U330, F-33076 Bordeaux, France Hosp Germans Trias & Pujol, Badalona, Spain Hosp Germans Trias & Pujol Badalona Spain rias & Pujol, Badalona, Spain
Titolo Testata:
AIDS
fascicolo: 1, volume: 15, anno: 2001,
pagine: 23 - 31
SICI:
0269-9370(20010105)15:1<23:DOMTFC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PNEUMOCYSTIS-CARINII PNEUMONIA; AIDS PATIENTS; LYMPHOCYTE-RESPONSES; PROTEASE INHIBITORS; CMV RETINITIS; CD4+ COUNTS; DISEASE; PROPHYLAXIS; GANCICLOVIR; ANTIGENEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Katlama, C Hop La Pitie Salpetriere, Dept Infect Dis, 47-83 Bld Hop, F-75013 Paris, France Hop La Pitie Salpetriere 47-83 Bld Hop Paris France F-75013 ce
Citazione:
M. Jouan et al., "Discontinuation of maintenance therapy for cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy", AIDS, 15(1), 2001, pp. 23-31

Abstract

Objective: To study the safety of discontinuing cytomegalovirus (CMV) maintenance therapy among patients with cured CMV retinitis receiving highly active antiretroviral therapy (HAART). Methods: Patients with a history of CMV retinitis who were receiving anti-CMV maintenance therapy and who had a CD4 cell count > 75 x 10(6) cells/l and a plasma HIV RNA level < 30 000 copies/ml while on HAART were included in a multicentre prospective study. Maintenance therapy for CMV retinitis was discontinued at enrolment and all the patients were monitored for 48 weeks by ophthalmological examinations and by determination of CMV markers, CD4cell counts and plasma HIV RNA levels. T helper-1 anti-CMV responses were assessed in a subgroup of patients. The primary study endpoint was recurrence of CMV disease. Results: At entry, the 48 assessable patients had been taking HAART for a median of 18 months. The median CD4 cell count was 239 x 10(6) cells/l and the median HIV RNA load was 213 copies/ml. Over the 48 weeks, 2 of the 48 patients had a recurrence of CMV disease. The cumulative probability of CMV retinitis relapse was 2.2% at week 48 (95% confidence interval, 0.4-11.3) and that of all forms of CMV disease 4.2%. CMV blood markers remained negative throughout follow-up. The proportion of patients with CMV-specific CD4 Tcell reactivity was 46% at baseline and 64% at week 48. Conclusions: CMV retinitis maintenance therapy may be safely discontinued in patients with CD4 cell counts above 75 x 10(6) cells/l who have been taking HAART for at least 18 months. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:14:37