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Titolo:
Physiological concentrations of nicotine do not affect prostacyclin, thromboxane or PGE production from perfused human umbilical veins
Autore:
Cook, JL; Keith, BA; White, NM; Randall, CL;
Indirizzi:
Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 col, Edmonton, AB T6G 2S2, Canada Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Sci, Charleston, SC 29425 USA
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 63 - 71
SICI:
1355-6215(200101)6:1<63:PCONDN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-E PRODUCTION; PLACENTAL CIRCULATION; REDUCES PROSTACYCLIN; ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; VASCULAR TONE; BIRTH-WEIGHT; EXPOSURE; ETHANOL; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Cook, JL 214H Reid Rd, Saskatoon, SK S7N 3C1, Canada 214H Reid Rd Saskatoon SK Canada S7N 3C1 oon, SK S7N 3C1, Canada
Citazione:
J.L. Cook et al., "Physiological concentrations of nicotine do not affect prostacyclin, thromboxane or PGE production from perfused human umbilical veins", ADDICT BIOL, 6(1), 2001, pp. 63-71

Abstract

Smoking during pregnancy is associated with a number of maternal and fetalcomplications. The mechanisms underlying the effects of nicotine on fetal growth and develop ment are not known, but may involve decreases in umbilical-placental blood flow. Prostaglandins are vasoactive mediators that regulate umbilical-placental blood flow and there is evidence that nicotine may alter prostaglandin production. Thus, alterations in vasoactive prostaglandins from the human umbilical vein may explain nicotine-induced decreases invessel blood flow and may under lie some of the negative effects of nicotine on the fetus. This study was designed to deter mine the relationship between nicotine and human umbilical vein prostaglandin production. Prostacyclin, thromboxane and prostaglandin E were measured from human umbilical veins collected from women at the time of cesarean section. Vessels were perfused with either vehicle (Dulbecco's modified Eagle's media), 5 mM, 10 mM or 20 mM nicotine for 60 minutes. Samples were collected from the perfusate after 5, 15, 30 and 60 minutes of perfusion, and prostaglandins were measuredby radioimmunoassay. Data were analyzed by ANOVA. Perfusion with 10 mM or 20 mm significantly reduced prostacyclin product ion by the human umbilicalveins, but nicotine did not affect prostaglandin E. The effects of nicotine on thromboxane were less clear. However, nicotine concentrations requiredto illicit an effect on prostacyclin production were much larger than circulating levels associated with smoking, so it is only pharmacological concentrations that have a significant effect. Thus, nicotine-induced alterations in umbilical vein prostaglandin production does not appear to be a mechanism by which nicotine adversely affects fetal growth and development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:12:21