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Titolo:
The acute cardiovascular effects of 3,4-methylenedioxymethamphetamine (MDMA) and p-methoxyamphetamine (PMA)
Autore:
Irvine, RJ; Toop, NP; Phillis, BD; Lewanowitsch, T;
Indirizzi:
Univ Adelaide, Dept Clin & Expt Pharmacol, Adelaide, SA 5005, Australia Univ Adelaide Adelaide SA Australia 5005 ol, Adelaide, SA 5005, Australia
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 45 - 54
SICI:
1355-6215(200101)6:1<45:TACEO3>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; HEART-RATE; SEROTONIN; ECSTASY; DOPAMINE; RELEASE; BRAIN; NEURONS; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Irvine, RJ Univ Adelaide, Dept Clin & Expt Pharmacol, GPO Box 498, Adelaide, SA 5005,Australia Univ Adelaide GPO Box 498 Adelaide SA Australia 5005 ,Australia
Citazione:
R.J. Irvine et al., "The acute cardiovascular effects of 3,4-methylenedioxymethamphetamine (MDMA) and p-methoxyamphetamine (PMA)", ADDICT BIOL, 6(1), 2001, pp. 45-54

Abstract

A number of reports of severe acute toxicity as a result of recreational ingestion of what was believed to be 3,4-methylenedioxymethamphetamine (MDMA) (ecstasy) have revealed, on chemical analysis of the victim's blood, to be due to p-methoxyamphetamine (PMA). Increased blood pressure and heart rate have been associated with this toxicity, which is exacerbated by high ambient temperature. We compared MDMA and PMA effects on blood pressure and heart rate in conscious freely moving rats at ambient temperatures of 20 degreesC and 30 degreesC. Drugs were administered at 5, 10, 15 and 20 mg/kg s.c. and cardiovascular recordings continued 2-4 hours post-drug. At 20 degreesC MDMA had a slight lowering effect on blood pressure or heart rate at alldoses tested. In contrast, PMA administered at the same ambient temperature caused a dose-de pendent long-lasting bradycardia and lowering of blood pressure. At 30 degreesC MDMA caused a slight increase in heart rate and a moderate rise in blood pressure. PMA did not significantly change heart rateor blood pressure at any of the doses tested. ECG was only influenced at the highest dose (20 mg/kg) of PMA and MDMA administered at 30 degreesC where ST elongation was observed. These data indicate that although these drugsare consider ed similar in their psychotrophic effects they have differentactions on the cardiovascular system of the rat. These findings may have implications in the diagnosis and emergency treatment of victims of MDMA/PMAtoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:45:11