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Titolo:
Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals
Autore:
Imamura, Y; Uchida, A; Takada, H; Otagiri, M; Tsuchiya, K;
Indirizzi:
Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan Kumamoto Univ Kumamoto Japan 8620973 maceut Sci, Kumamoto 8620973, Japan Miyazaki Med Coll, Expt Anim Ctr, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan
Titolo Testata:
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
fascicolo: 1, volume: 121, anno: 2001,
pagine: 85 - 91
SICI:
0031-6903(200101)121:1<85:SSASDO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
JPN
Soggetto:
3-ALPHA-HYDROXYSTEROID DEHYDROGENASE; POSTNATAL-DEVELOPMENT; WISTAR RATS; METABOLISM; CYTOSOL; GLUCURONYLTRANSFERASE; ANDROSTERONE; DRUG;
Keywords:
acetohexamide reductase; 20 beta-hydroxysteroid dehydrogenase; strain-related difference; male-specific microsomal enzyme; species-related difference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Imamura, Y Kumamoto Univ, Fac Pharmaceut Sci, 5-1 Oe Honmachi, Kumamoto 8620973, Japan Kumamoto Univ 5-1 Oe Honmachi Kumamoto Japan 8620973 73, Japan
Citazione:
Y. Imamura et al., "Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals", YAKUGAKU ZA, 121(1), 2001, pp. 85-91

Abstract

We examined physiological and genetic factors affecting acetohexamide reductase (AHR) and 20 beta -hydroxysteroid dehydrogenase (20 beta -HSD) activities in liver microsomes of experimental animals. Pronounced strain-relateddifferences were found in both activities of AHR and 20 beta -HSD present in liver microsomes of male rats. Among rat strains tested in this study, even though a Wistar-Imamichi (WIM) rat strain was taken to lack AHR activity, it exhibited a significant 20 beta -HSD activity. These findings appeared to be in conflict with our conclusion reported so far, which AHR and 20 beta -HSD present in liver microsomes of male rats are identical enzymes. Thus the reason for this discrepancy was discussed. Furthermore, AHR and 20 beta -HSD activities were little or not observed in liver microsomes of female rats or male experimental animals other than the rat, indicating the existence of sex- and species-related differences in these two enzyme activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:14:32