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Titolo:
Mutational analysis of the beta-catenin gene in gastric carcinomas
Autore:
Sasaki, Y; Morimoto, I; Kusano, M; Hosokawa, M; Itoh, F; Yanagihara, K; Imai, K; Tokino, T;
Indirizzi:
Sapporo Med Univ, Sch Med, Canc Res Inst, Dept Mol Biol,Chuo Ku, Sapporo, Hokkaido 0608556, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608556 , Hokkaido 0608556, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 1, Sapporo, Hokkaido 0608556,Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608556 o, Hokkaido 0608556,Japan Keiyukai Sapporo Hosp, Sapporo, Hokkaido, Japan Keiyukai Sapporo Hosp Sapporo Hokkaido Japan p, Sapporo, Hokkaido, Japan Natl Canc Ctr, Res Inst, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104Natl Canc Ctr, Res Inst, Tokyo 104, Japan
Titolo Testata:
TUMOR BIOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 123 - 130
SICI:
1010-4283(200103/04)22:2<123:MAOTBG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOMATOUS POLYPOSIS-COLI; E-CADHERIN; ALPHA-CATENIN; SOMATIC MUTATIONS; COLORECTAL-CANCER; CELL-LINES; APC GENE; HEPATOCELLULAR CARCINOMAS; BREAST CARCINOMAS; EXPRESSION;
Keywords:
beta-catenin; gastric carcinoma, human; immunohistochemistry; somatic mutation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Tokino, T Sapporo Med Univ, Sch Med, Canc Res Inst, Dept Mol Biol,Chuo Ku,S-1,W-17,Sapporo, Hokkaido 0608556, Japan Sapporo Med Univ S-1,W-17 Sapporo Hokkaido Japan 0608556 , Japan
Citazione:
Y. Sasaki et al., "Mutational analysis of the beta-catenin gene in gastric carcinomas", TUMOR BIOL, 22(2), 2001, pp. 123-130

Abstract

Previous studies reported that mutation of the adenomatous polyposis coli (APC) gene was not observed in the majority of gastric cancers. To evaluatethe role of the APC/beta -catenin/Tcf pathway, we analyzed mutations in the beta -catenin gene and the accumulation of beta -catenin protein in gastric carcinomas. An interstitial deletion spanning exon 3 of the beta -catenin gene was observed in 1 of 13 gastric cancer cell lines. No missense mutation was found in these 13 cell lines. Nuclear and/or cytoplasmic localization of beta -catenin was observed in 16 of 70 primary gastric carcinomas by immunohistochemistry, while we found no mutations in exon 3 in 35 carcinomatissues available for PCR amplification. Our findings suggest that somaticmutations of the beta -catenin gene are rare in human gastric carcinomas and that accumulation of normal beta -catenin protein in a subset of gastriccancers may be due to other mechanisms of its activation. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:46:46