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Titolo:
The cell biology and physiologic relevance of apoE recycling
Autore:
Fazio, S; Linton, MF; Swift, LL;
Indirizzi:
Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Pathol, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA
Titolo Testata:
TRENDS IN CARDIOVASCULAR MEDICINE
fascicolo: 1, volume: 10, anno: 2000,
pagine: 23 - 30
SICI:
1050-1738(200001)10:1<23:TCBAPR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; RECEPTOR-MEDIATED ENDOCYTOSIS; HEPARAN-SULFATE PROTEOGLYCANS; MOUSE PERITONEAL-MACROPHAGES; B-CONTAINING LIPOPROTEINS; PROTEIN-KINASE-C; APOLIPOPROTEIN-E; CHYLOMICRON REMNANTS; III HYPERLIPOPROTEINEMIA; TRANSGENIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Fazio, S Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Dept Med, 315 MRB II, Nashville, TN 37232 USA Vanderbilt Univ 315 MRB II Nashville TN USA 37232 e, TN 37232 USA
Citazione:
S. Fazio et al., "The cell biology and physiologic relevance of apoE recycling", TREND CARD, 10(1), 2000, pp. 23-30

Abstract

Apolipoprotein E (apoE) is unique among the different apoproteins because of its many functions in the assembly, processing, and removal of plasma lipoproteins. Some of these functions require the presence of apoE inside thecell or in close association with its outer membrane. For example, the presence of apoE increases triglyceride content in newly formed very low-density lipoprotein (VLDL), whereas the fast removal of chylomicrons requires the presence of a cellular pool of apoE ready, to surface and bind to membrane proteoglycans and possibly to lipoprotein receptors such as the LDL receptor-related protein (LRP). Our recent discovery that VLDL-apoE internalizedby hepatocytes is partially protected from lysosomal degradation and recycles through the Golgi apparatus suggests that the biologic cycle of apoE may not be concluded when the lipoprotein is taken up by the cell, and that recycling apoE may have a physiologic role in lipoprotein assembly, remnant removal, and cholesterol efflux. (Trends Cardiovasc Med 2000; 10:23-30). (C) 2000, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:48:11