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Titolo:
Endogenous clotting factor activity and long-term outcome in patients withmoderate haemophilia
Autore:
Fischer, K; van der Bom, JG; Mauser-Bunschoten, EP; Roosendaal, G; Beek, FJA; de Kleijn, P; Grobbee, DE; van den Berg, HM;
Indirizzi:
Univ Utrecht, Med Ctr, Van Creveldklin HP C01425, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Julius Ctr Gen Practice & Patient Oriented Res, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Radiol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Rehabil & Nutr Sci, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 6, volume: 84, anno: 2000,
pagine: 977 - 980
SICI:
0340-6245(200012)84:6<977:ECFAAL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHILIA-A; PROPHYLAXIS;
Keywords:
moderate haemophilia; Pettersson score; haemarthrosis; arthropathy; prophylactic treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Fischer, K Univ Utrecht, Med Ctr, Van Creveldklin HP C01425, POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA herlands
Citazione:
K. Fischer et al., "Endogenous clotting factor activity and long-term outcome in patients withmoderate haemophilia", THROMB HAEM, 84(6), 2000, pp. 977-980

Abstract

In order to address the question of the optimum target level for prophylactic treatment of severe haemophilia patients, the association between endogenous clotting factor activity and outcome was studied in a cohort of 46 patients with moderate haemophilia. Data on treatment and outcome were collected annually. Median follow-up was 8.0 years (range 1-26). Median joint bleed frequency was 1 per year and median radiological score according to Pettersson was 1 point (max. 78) at the age of 25 years. One percent increase in clotting factor level was associated with a 4 months later onset of joint bleeds (95% Confidence Interval (CI): 2-6 months) and a 16% lower Pettersson score (95%CI: 3-27%). No statistically significant effect of clotting factor activity on joint bleed frequency could be demonstrated. These findings confirm that patients with moderate haemophilia experience only mild arthropathy, and provide evidence for a protective effect of higher clotting factor levels on joint damage.

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Documento generato il 01/10/20 alle ore 03:52:27