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Titolo:
Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse
Autore:
Cho, AK; Melega, WP; Kuczenski, R; Segal, DS;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat 0603, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t 0603, La Jolla, CA 92093 USA Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA USA UnivCalif Los Angeles Los Angeles CA USA Pharmacol, Los Angeles, CA USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 161 - 166
SICI:
0887-4476(200102)39:2<161:ROPPIA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STEREOTYPED BEHAVIORS; POSITRON-EMISSION-TOMOGRAPHY; ACUTE RESPONSE; AMPHETAMINE PSYCHOSIS; NUCLEUS-ACCUMBENS; C-11 WIN-35,428; DOPAMINE; COCAINE; SENSITIZATION; TOLERANCE;
Keywords:
methamphetamine; animal models; pharmacokinetics; drug abuse; binge;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kuczenski, R Univ Calif San Diego, Sch Med, Dept Psychiat 0603, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 lla, CA 92093 USA
Citazione:
A.K. Cho et al., "Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse", SYNAPSE, 39(2), 2001, pp. 161-166

Abstract

Although the behavioral consequences of methamphetamine (METH) abuse have been extensively documented, a more precise and thorough understanding of underlying neurobiological mechanisms still requires the use of animal models. To study these biochemical processes in experimental animals requires consideration for the broad range of human METH abuse patterns and the many factors that have been identified to profoundly influence the behavioral andneurochemical effects of exposure to METH-like stimulants. One potentiallycritical issue relates to pharmacokinetic differences between the species. In this review, METH plasma pharmacokinetic profiles after single and multiple dose intravenous METH administration are compared for the rat and human. Significant differences in elimination half-life between the two species(t(1/2) rat-70 min, human-12 h) result in markedly dissimilar profiles of METH exposure. However, the plasma profile of a human METH binge pattern can be approximated in the rat by increasing METH dose frequency. Consideration of METH pharmacokinetics in animal models should permit a closer simulation of the temporal profile of METH exposure in the human CNS and should provide further insight into the mechanisms contributing to the addiciton andpsychopathology associated with METH abuse. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:01:57