Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways
Autore:
Sakai, K; Gao, XM; Hashimoto, T; Tamminga, CA;
Indirizzi:
Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USAUniv Maryland Baltimore MD USA 21228 iat Res Ctr, Baltimore, MD 21228 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 152 - 160
SICI:
0887-4476(200102)39:2<152:TANADD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VACUOUS CHEWING MOVEMENTS; GLUTAMIC-ACID DECARBOXYLASE; MIDBRAIN DOPAMINE NEURONS; ANTI-SCHIZOPHRENIC DRUGS; TARDIVE-DYSKINESIA; RAT-BRAIN; LONG-TERM; SUBSTANTIA-NIGRA; OLANZAPINE TRIAL; MESSENGER-RNAS;
Keywords:
antipsychotic drugs; schizophrenia; olanzapine; sertindole; haloperidol; dopamine receptors; GABA receptors; GAD(67) mRNA; enkephalin mRNA; substance P mRNA; rats; chronic drug treatment; VCM; tardive dyskinesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Tamminga, CA Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, POB 21247,Maple & Locust St, Baltimore, MD 21228 USA Univ Maryland POB 21247,Maple & Locust St Baltimore MD USA 21228
Citazione:
K. Sakai et al., "Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways", SYNAPSE, 39(2), 2001, pp. 152-160

Abstract

The effects of three chronically administered antipsychotic drugs on selected neurochemical markers of dopaminergic and GABAergic transmission were compared within the cerebral regions making up the basal ganglia-thalamocortical parallel processing neuronal pathways. All three drugs reduce psychosis in humans, whereas only haloperidol, but not olanzapine or sertindole, induce purposeless oral chewing movements (CMs) in rats or cause high rates of parkinsonism or tardive dyskinesia in humans. Male Sprague Dawley rats were treated with haloperidol, sertindole, or olanzapine delivered in drinking water for 6 months at doses which produce drug plasma levels in rat in the human therapeutic range. Results show the expected dopamine D-2 receptor upregulation in striatum predominantly with haloperidol, although mild D-2 upregulation was apparent in striatum after olanzapine. GAD(67) mRNA was increased in striatum and decreased in globus pallidus by haloperidol and sertindole, but not by olanzapine. In the substantia nigra pars reticulata (SNR), both olanzapine and sertindole failed to induce GABA, receptor upregulation or D-2 receptor downregulation, but haloperidol did both, confirming aprevious report. In thalamus, all three drugs increased GAD expression in the reticular nucleus, whereas only haloperidol decreased GABA(A) binding in the mediodorsal nucleus, actions consistent with a reduction in nigrothalamic, GABA-mediated neural transmission. These results are consistent with the idea that the two new antipsychotics tested have mild and regionally restricted actions within the basal ganglia nuclei and a common action on increasing GAD expression in the reticular nucleus of the thalamus (RtN). Haloperidol, in contrast, has a broad and potent action in basal ganglia, causing changes in SNR and in the mediodorsal nucleus, while also altering GAD mRNA in RtN, potentially reflective of its dyskinetic and antipsychotic actions. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:55:55