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Titolo:
Anatomic basis of sequence-dependent predictability exhibited by nigral dopamine neuron firing patterns
Autore:
Hoffman, RE; Shi, WX; Bunney, BS;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Pharmacol, New Haven, CT 06520 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 133 - 138
SICI:
0887-4476(200102)39:2<133:ABOSPE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; SPIKE TRAINS; DETERMINISTIC VARIABILITY; SUBTHALAMIC NUCLEUS; FAVORED PATTERNS; CELL-ACTIVITY; MOTOR CORTEX; RAT; DYNAMICS; RECONSTRUCTION;
Keywords:
neuron; dopamine; substantia nigra; firing pattern; sequence-dependent prediction; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffman, RE Yale Univ, Sch Med, Dept Psychiat, POB 208099, New Haven, CT 06520 USA Yale Univ POB 208099 New Haven CT USA 06520 aven, CT 06520 USA
Citazione:
R.E. Hoffman et al., "Anatomic basis of sequence-dependent predictability exhibited by nigral dopamine neuron firing patterns", SYNAPSE, 39(2), 2001, pp. 133-138

Abstract

Interspike intervals (ISIs) of dopamine (DA) neurons recorded in the substantia nigra are predicted partially by their immediate prior history. This study was designed to assess neuroanatomic origins of these sequential relationships. ISI data recorded from three groups of nigral DA neurons were studied: 1) 16 neurons recorded in unlesioned animals, 2) 14 neurons recordedafter forebrain hemisection, 3) 12 neurons recorded after partial forebrain hemisection that reproduced nonspecific effects of the surgical lesion while leaving forebrain connections intact. As predicted, DA neurons recordedafter full forebrain hemisection yielded statistically significant reductions in sequential predictability relative to control neurons and neurons recorded following partial hemisection. These data support the hypothesis that the sequence-dependent behavior of DA neurons arise in part from interactions with forebrain structures. ISI sequences recorded from unlesioned ratsdemonstrated maximum predictability when an average of 3.7 prior events were incorporated into the forecasting algorithm, thereby suggesting a physiological process whose "depth" of history-dependence is approximately 600-800 msec. Additional studies examining the functional significance of sequence-dependent ISI structure exhibited by nigral DA neurons are indicated. (C)2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 20:59:43