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Titolo:
FosB in rat striatum: Normal regional distribution and enhanced expressionafter 6-month haloperidol administration
Autore:
Rodriguez, JJ; Garcia, DR; Nakabeppu, Y; Pickel, VM;
Indirizzi:
Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rol & Neurosci, New York, NY 10021 USA Kyushu Univ, Med Inst Bioregulat, Dept Biochem, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 oregulat, Dept Biochem, Fukuoka 812, Japan
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 122 - 132
SICI:
0887-4476(200102)39:2<122:FIRSNR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; ATYPICAL ANTIPSYCHOTIC-DRUGS; VACUOUS CHEWING MOVEMENTS; MESSENGER-RNA EXPRESSION; LONG-TERM HALOPERIDOL; C-FOS; DELTA-FOSB; DENDRITIC SPINES; CAUDATE-PUTAMEN; BASAL GANGLIA;
Keywords:
neuroleptic; caudate-putamen nucleus; immediate early gene; schizophrenia; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez, JJ Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, 411 E69th St, New York, NY 10021 USA Cornell Univ 411 E 69th St New York NY USA 10021 Y 10021 USA
Citazione:
J.J. Rodriguez et al., "FosB in rat striatum: Normal regional distribution and enhanced expressionafter 6-month haloperidol administration", SYNAPSE, 39(2), 2001, pp. 122-132

Abstract

Subcortical motor nuclei show differential expression of FosB immediate early gene products and specifically Delta FosB after short (8, 19, or 21 days) chronic exposure to typical and atypical neuroleptics represented by haloperidol and clozapine, respectively. We quantitatively examined whether there are light microscopic regional variations in area density of FosB or the truncated Delta FosB in several motor-related nuclei of adult rats receiving vehicle or long chronic (6 months) administration of either depot haloperidol or clozapine in their drinking water. In control animals the dorsomedial and ventromedial caudate-putamen nucleus (CPN) had a significantly higher density of FosB-immunoreactive cells than the dorsolateral and ventrolateral regions. The nucleus accumbens (NAc) core also serving motor functions had a higher basal expression than the limbic shell region in control animals. The mediolateral gradient in area density of FosB-labeled cells was maintained in animals receiving either haloperidol or clozapine. In animals receiving haloperidol, but not clozapine, however, there was a regionally selective increase in the area density of only FosB-immunoreactive neurons in the dorsolateral and ventrolateral CPN and in both the core and shell of the NAc. Only the animals receiving chronic haloperidol showed vacuous chewing movements, the animal equivalent of tardive dyskinesia in humans. Our results suggest that, whereas the medial striatal neurons are activated under basal conditions, long chronic haloperidol induced FosB expression more exclusively in the lateral CPN and NAc core, implicating these regions specifically in the motor side effects of this drug. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:22:22