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Titolo:
Compensatory responses in the aging hippocampal serotonergic system following neurodegenerative injury with 5,7-dihydroxytryptamine
Autore:
Dugar, A; Keck, BJ; Maines, LW; Miller, S; Njai, R; Lakoski, JM;
Indirizzi:
Penn State Univ, Coll Med, Dept Pharmacol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 ept Pharmacol, Hershey, PA 17033 USA Penn State Univ, Coll Med, Dept Anesthesiol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 t Anesthesiol, Hershey, PA 17033 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 109 - 121
SICI:
0887-4476(200102)39:2<109:CRITAH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; ADULT-RAT HIPPOCAMPUS; FRONTAL-CORTEX; MESSENGER-RNA; DORSAL RAPHE; HUMAN BRAIN; NEURONS; AGE; TRANSPORTER; IMIPRAMINE;
Keywords:
serotonin (5-hydroxytryptamine; 5-HT); aging; serotonin transporter (5-HTT); hippocampus; 5,7-dihydroxytryptamine (5,7-DHT); immunohistochemistry; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Lakoski, JM Penn State Univ, Coll Med, Dept Pharmacol, H078,500 Univ Dr, Hershey, PA 17033 USA Penn State Univ H078,500 Univ Dr Hershey PA USA 17033 7033 USA
Citazione:
A. Dugar et al., "Compensatory responses in the aging hippocampal serotonergic system following neurodegenerative injury with 5,7-dihydroxytryptamine", SYNAPSE, 39(2), 2001, pp. 109-121

Abstract

This study utilized a multidisciplinary approach to examine injury-inducedcompensatory responses in the aging hippocampal serotonin transporter (5-HTT), a membrane protein implicated in a variety of neurodegenerative disorders. Age-dependent cellular, anatomical, and physiological changes of the 5-HTT were evaluated in female Fischer 344 rats (2 and 17 months) following denervation of the serotonergic afferents (fimbria-fornix and cingulum bundle) to the dorsal hippocampus using the neurotoxicant 5,7-dihydroxytryptamine (5,7-DHT). Seven days following 5,7-DHT administration, a uniform loss of the hippocampal 5-HTT immunoreactivity was observed in both age groups. However, at 21 days 5-HTT immunoreactivity in young 5,7-DHT-treated animals was similar to control levels, indicative of recovery, while older animals exposed to 5,7-DHT did not show recovery of hippocampal 5-HTT expression. 5-HTT binding site density, as determined by quantitative autoradiography ([H-3]citalopram), supported the immunohistochemical results by demonstratinga recovery of 5-HTT binding sites in young, but not old animals, at 21 days following the lesion(P < 0.001). Furthermore, cellular electrophysiological function of hippocampal CA1 pyramidal neurons in 3- and 18-month-old F344 rats at 21 days following 5,7-DHT or vehicle treatment were assessed using in vivo microiontophoretic application of serotonin (5-HT). Independent of changes in sensitivity to the inhibitory effects of 5-HT application, thetime to recovery of cell firing following application of 5-HT was significantly increased in the 18-month 5,7-DHT group compared to the 18-month vehicle and S-month 5,7-DHT groups (60 and 59% increases, respectively; P < 0.05). Overall, these series of studies comprise a model which can be used to identify cellular events underlying both the formation of injury-induced compensatory processes in younger animals and the lack thereof with advancingage. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:54:45