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Titolo:
High social anxiety and low aggression in Fawn-Hooded rats
Autore:
Kantor, S; Anheuer, ZE; Bagdy, G;
Indirizzi:
Natl Inst Psychiat & Neurol, Lab Neurochem & Expt Med, H-1021 Budapest, Hungary Natl Inst Psychiat & Neurol Budapest Hungary H-1021 21 Budapest, Hungary
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 5, volume: 71, anno: 2000,
pagine: 551 - 557
SICI:
0031-9384(200012)71:5<551:HSAALA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; PANIC DISORDER PATIENTS; SPRAGUE-DAWLEY RATS; META-CHLOROPHENYLPIPERAZINE; IMIPRAMINE BINDING; 5-HT1A RECEPTOR; SEROTONIN FUNCTION; CHRONIC FLUOXETINE; PLATELET BINDING; HEALTHY-SUBJECTS;
Keywords:
serotonin (5-HT); Fawn-Hooded rat; social interaction test; social phobia; anxiety; aggression; animal model; 5-HT2C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Bagdy, G Natl Inst Psychiat & Neurol, Lab Neurochem & Expt Med, POB 1,Huvosvolgyi Ut 116, H-1021 Budapest, Hungary Natl Inst Psychiat & Neurol POB 1,Huvosvolgyi Ut 116 Budapest Hungary H-1021
Citazione:
S. Kantor et al., "High social anxiety and low aggression in Fawn-Hooded rats", PHYSL BEHAV, 71(5), 2000, pp. 551-557

Abstract

The Fawn-Hooded (FH) rat strain, with well-documented changes in their serotonergic and noradrenergic systems, is a putative genetic model for some neuropsychiatric disorders like depression, alcohol abuse, and anxiety. Because social phobia frequently occurs in combination with these disorders andthere are no social anxiety-related data in FH rats in the literature, we measured the behavior of FH rats in the social interaction test. In addition, the effects of the anxiogenic Serotonin-2C (5-HT2C) receptor agonist, m-chlorophenylpipcrazine (m-CPP), were studied. Male FH, Wistar (W), and Sprague-Dawley (SD) rats were used in two different test conditions of the social interaction test: the high light, unfamiliar arena, associated with highanxiety, and the low light, familiar arena, associated with low anxiety-like behavior. All social behaviors were markedly diminished in FH rats that suggested higher anxiety in these animals. Total social interaction time was reduced by 60-70% in FH rats compared either to W or SD rats under high light, unfamiliar or low light, familiar conditions, respectively. Aggressive behavior was reduced at least by 85% in FH rats. Locomotor activity and exploratory behavior were only minimally, in most comparisons, not significantly affected in FH rats. Total social interaction time, aggression, and locomotor activity were decreased, and self-grooming increased by m-CPP (0.5 mg/kg, ip) in all three strains. m-CPP decreased total social interaction time thus, caused anxiety most efficiently in FH rats (reduced by 69%, 50%, and 55% in FH, W, and SD rats, respectively), but other effects of the drugwere similar in the three strains. Our studies provide evidence that the FH rat strain may be a genetic model of social phobia or other anxiety disorders with impaired social behavior. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:33:15