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Titolo:
Additive satiety-delaying effects of capsaicin-induced visceral deafferentation and NMDA receptor blockade suggest separate pathways
Autore:
Berthoud, HR; Patterson, LM; Morales, S; Zheng, HY;
Indirizzi:
Louisiana State Univ, Pennington Biomed Res Ctr, Neurobiol Nutr Lab, BatonRouge, LA 70808 USA Louisiana State Univ Baton Rouge LA USA 70808 b, BatonRouge, LA 70808 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 67, anno: 2000,
pagine: 371 - 375
SICI:
0091-3057(200010)67:2<371:ASEOCV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARII; METABOTROPIC GLUTAMATE RECEPTORS; D-ASPARTATE RECEPTORS; METHYL-D-ASPARTATE; MEDULLA-OBLONGATA; NERVOUS-SYSTEM; FOOD-INTAKE; RAT; TRANSMISSION; MK-801;
Keywords:
vagal afferents; visceral satiety signals; gastric distension; primary afferents; caudal brainstem; hindbrain; NTS; glutamate; N-methyl-D-aspartate receptor; satiation; meal termination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Berthoud, HR Louisiana State Univ, Pennington Biomed Res Ctr, Neurobiol Nutr Lab, BatonRouge, LA 70808 USA Louisiana State Univ Baton Rouge LA USA 70808 , LA 70808 USA
Citazione:
H.R. Berthoud et al., "Additive satiety-delaying effects of capsaicin-induced visceral deafferentation and NMDA receptor blockade suggest separate pathways", PHARM BIO B, 67(2), 2000, pp. 371-375

Abstract

Both ablation of visceral afferents and blockade of NMDA receptor-mediatedglutamatergic transmission by MK-801 result in overconsumption of sucrose solution and other food, apparently by interrupting Visceral signals and thus delaying satiation. If these two manipulations act on the same pathway, namely, the propagation of vagal afferent signals to NTS neurons, their effects would be expected to be non-additive. To test this hypothesis, two groups of rats - one with prior systemic capsaicin (n = 11) and one with vehicle treatment (n = 10) - were trained to drink 15% sucrose solution after 15h food deprivation every 3-4 days, and then injected with MK-801 (100 mug/kg, i.p.) or saline. Both capsaicin and MK-801 produced the expected significant (p<.001) increase in 30 and 60 min sucrose intake if compared to their respective controls. Administration of MK-801 to capsaicin-treated rats further increased 60 min sucrose intake significantly (p<.001) in a fully additive fashion. These results suggest that the two treatments do not impinge on the same neural pathway to delay satiation. MK-801 may interfere with signals from capsaicin-resistant vagal afferents, or alternatively may act on other areas in the brain or periphery. (C) 2000 Elsevier Science Inc. All rights reserved.

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Documento generato il 21/10/20 alle ore 04:47:57