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Titolo:
Effects of ethanol on startle responding in alcohol-preferring and -non-preferring rats
Autore:
Jones, AE; McBride, WJ; Murphy, JM; Lumeng, L; Li, TK; Shekhar, A; McKinzie, DL;
Indirizzi:
Indiana Univ, Sch Med, Inst Psychiat Res, Program Med Neurobiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 robiol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ychiat, Indianapolis, IN 46202 USA Indiana Univ Purdue Univ, Purdue Sch Sci, Dept Psychol, Indianapolis, IN 46202 USA Indiana Univ Purdue Univ Indianapolis IN USA 46202 anapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med & Biochem, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iochem, Indianapolis, IN 46202 USA VA Med Ctr, Indianapolis, IN USA VA Med Ctr Indianapolis IN USAVA Med Ctr, Indianapolis, IN USA Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 oxicol, Indianapolis, IN 46202 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 67, anno: 2000,
pagine: 313 - 318
SICI:
0091-3057(200010)67:2<313:EOEOSR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-CHOICE DRINKING; PREPULSE INHIBITION; ACOUSTIC STARTLE; ANXIETY DISORDERS; P-RATS; MESOLIMBIC DOPAMINE; NONPREFERRING LINES; SELF-INFUSION; ANIMAL-MODEL; NP-RATS;
Keywords:
acoustic startle response; prepulse inhibition; alcohol-preferring P rats; alcohol-non-preferring NP rats; anxiety; sensorimotor gating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: McBride, WJ Indiana Univ, Sch Med, Inst Psychiat Res, Program Med Neurobiol, 791 UnionDr, Indianapolis, IN 46202 USA Indiana Univ 791 Union Dr Indianapolis IN USA 46202 46202 USA
Citazione:
A.E. Jones et al., "Effects of ethanol on startle responding in alcohol-preferring and -non-preferring rats", PHARM BIO B, 67(2), 2000, pp. 313-318

Abstract

The objectives of the present study were to determine (a) if differences exist between the selectively bred alcohol-preferring (P) and -nonpreferring(NP) lines of rats in the acoustic startle response (ASR) and prepulse inhibition (PPI), and (6) the effects of ethanol on these measures. Alcohol-naive adult female P and NP rats received a single i.p. injection of saline or ethanol (0.25, 0.5, 1.0, or 1.5 g/kg) and were placed in the startle apparatus 10 min later. After a 5-min acclimation period, rats received five alternating trials of a startle stimulus alone (SSA) (115-dB white noise) or a PPI trial (90-dB white noise preceding a 115-dB white noise). Analysis ofthe ASR revealed that P rats exhibited higher startle amplitudes than did NP rats with saline injections. The 0.5-g/kg ethanol dose reduced the startle amplitude in P, but not NP, rats. The 1.0- and 1.5-g/kg ethanol doses nearly abolished the ASR in the NP line, whereas only the highest ethanol dose had this effect in the P line. Vehicle-heated P and NP rats exhibited comparable PPI levels, but only P rats showed a significant disruption (30%) at the 0.50-g/kg ethanol dose. Neither P nor NP rats were affected by ethanol treatment at the 0.25-g/kg dose. Overall, the results suggest that: (a) the difference in baseline ASR may indicate line differences in the neurocircuitry mediating this response, possibly reflecting higher innate levels ofemotional reactivity in the P line; (b) the P line may be more sensitive than the NP line to the effects of ethanol in reducing emotional reactivity;and (c) low-dose ethanol may have a greater disruptive effect on sensorimotor gating mechanisms in the P than NP rat. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:12:32