Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of MK801 and neuroleptics on prepulse inhibition: re-examination in two strains of rats
Autore:
Bast, T; Zhang, WN; Feldon, J; White, IM;
Indirizzi:
Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 67, anno: 2000,
pagine: 647 - 658
SICI:
0091-3057(200011)67:3<647:EOMANO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-INDUCED DISRUPTION; SENSORIMOTOR GATING DEFICITS; ACOUSTIC STARTLE RESPONSE; ANIMAL-MODEL; SCHIZOPHRENIC-PATIENTS; TREATED RATS; CLOZAPINE; DIZOCILPINE; HALOPERIDOL; ANTIPSYCHOTICS;
Keywords:
prepulse inhibition; NMDA; dizocilpine; hippocampus; clozapine; haloperidol; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: White, IM Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16,Postfach, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16,Postfach Schwerzenbach Switzerland CH-8603
Citazione:
T. Bast et al., "Effects of MK801 and neuroleptics on prepulse inhibition: re-examination in two strains of rats", PHARM BIO B, 67(3), 2000, pp. 647-658

Abstract

Disruption of prepulse inhibition (PPI) induced by NMDA receptor antagonists, such as MK801, has been used as an animal model of positive and negative symptoms of schizophrenia. Previous studies suggested that atypical, but not typical, neuroleptics can selectively restore MK801-induced PPI disruption and that such selectivity may depend on strain differences. The presentstudy re-examined PPI disruption by systemic MK801 in Wistar (WS) and Sprague-Dawley (SD) strains, and addressed the issue whether clozapine (atypical), compared to haloperidol (typical), effectively antagonizes MK801-induced PPI disruption. In addition, we tested the effects of bilateral microinfusion of MK801 into the ventral hippocampus in WS. Systemic MK801 disrupted PPI in both strains. Neither clozapine nor haloperidol antagonized MK801-induced PPI in either strain. Our clozapine data do not agree with previous reports of clozapine's ability to antagonize MK801-induced PPI disruption. Similar to previous results with SD, MK801 infusion into the ventral hippocampus failed to affect PPI in WS. In our view, the selective ability of atypical neuroleptics to restore PPI disruption by NMDA antagonists, and to serve as a tool for identifying possible atypical neuroleptics, requires further examination. PPI disruption with systemic MK801 may be due to the blockade of NMDA receptors in multiple brain sites. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:30:45