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Titolo:
Ketamine blocks a taste recognition memory in fetal rats
Autore:
Mickley, GA; Remmers-Roeber, DR; Crouse, C; Peluso, R;
Indirizzi:
Baldwin Wallace Coll, Dept Psychol, Berea, OH 44017 USA Baldwin Wallace Coll Berea OH USA 44017 Dept Psychol, Berea, OH 44017 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 67, anno: 2000,
pagine: 575 - 581
SICI:
0091-3057(200011)67:3<575:KBATRM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONCOMPETITIVE NMDA ANTAGONIST; ASPARTATE RECEPTOR ANTAGONIST; LONG-TERM POTENTIATION; HIPPOCAMPAL DAMAGE; IMPLICIT MEMORY; AMNIOTIC-FLUID; SYSTEMS; RESPONSES; AVERSION; BRAIN;
Keywords:
taste recognition memory; fetus; neonate; rat; novelty; familiar; memory; saccharin; development; ketamine; NMDA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Mickley, GA Baldwin Wallace Coll, Dept Psychol, Carnegie Hall,275 EastlandRd, Berea, OH 44017 USA Baldwin Wallace Coll Carnegie Hall,275 Eastland RdBerea OH USA 44017
Citazione:
G.A. Mickley et al., "Ketamine blocks a taste recognition memory in fetal rats", PHARM BIO B, 67(3), 2000, pp. 575-581

Abstract

Decisions about novelty/familiarity are critical in determining whether ornot information should be attended to, and possibly encoded, for long-termstorage. We have reported that fetal and neonatal rats exhibit an increasein orofacial movements (e.g., perseverative mouthing and mouth movements, and licks) upon tasting saccharin (SAC), if it was experienced previously. E19 rat fetuses can acquire this taste recognition memory and retain it forat least 5 days (P3). In the current study, we sought to evaluate the roleof N-methyl-D-aspartate (NMDA) receptors in establishing a taste recognition memory. Pregnant Sprague-Dawley rats received ketamine (NMDA receptor antagonist) (doses: 0, 50, or 100 mg/kg, ip). One-half hour later, we performed a reversible spinal block on each pregnant dam, and E19 fetuses receivedan oral injection of 10 mul, 0.3% SAC or water (control) while in utero. The uterus was replaced and the pups were later born via a normal vaginal delivery. On P3, all pups experienced oral lavage of 10 mul, 0.3% SAC, and motor responses were recorded. As expected, non-drugged control neonates tasting familiar SAC exhibited significantly more perseverative mouth movements, as well as total mouth movements and licks, than did pups tasting novel SAC. However, this taste recognition memory response was not observed in rats exposed to ketamine in utero. The data suggest that early non-associativetaste memories may be disrupted by NMDA receptor blockade. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:16:34