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Titolo:
Dextromethorphan alters methamphetamine self-administration in the rat
Autore:
Jun, JH; Schindler, CW;
Indirizzi:
NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 ural Res Program,NIH, Baltimore, MD 21224 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 67, anno: 2000,
pagine: 405 - 409
SICI:
0091-3057(200011)67:3<405:DAMSIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR DOPAMINE; NUCLEUS-ACCUMBENS; BEHAVIORAL SENSITIZATION; INTRAVENOUS COCAINE; MORPHINE-TOLERANCE; NMDA RECEPTORS; TIME COURSE; AMPHETAMINE; COMBINATION; DEPENDENCE;
Keywords:
dextromethorphan; methamphetamine; self-administration; food control; NMDA antagonist; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Schindler, CW NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, Intramural Res Program,NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 D 21224 USA
Citazione:
J.H. Jun e C.W. Schindler, "Dextromethorphan alters methamphetamine self-administration in the rat", PHARM BIO B, 67(3), 2000, pp. 405-409

Abstract

Various lines of evidence indicate that methamphetamine (METH) self-administration in rats is under dopaminergic control, and NMDA receptors have been shown to control the release of dopamine at its synapse. Consequently, the aim of this study was to observe the effects of dextromethorphan (DM), a non-competitive NMDA antagonist, in rats self-administering METH. The hypothesis was that acute pretreatment of DM (25 mg/kg) would alter response to METH. DM significantly altered self-administration by reducing the number of correct responses for three METH self-administration doses (0.05, 0.1, 0.25 mg/kg). The same pretreatment did not affect responding for food reward. These findings show that the DM was able to selectively alter METH self-administration. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:33:25