Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanisms of angiogenesis and their use in the inhibition of tumor growthand metastasis
Autore:
Saaristo, A; Karpanen, T; Alitalo, K;
Indirizzi:
Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland Univ Helsinki, Haartman Inst, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 es, FIN-00014 Helsinki, Finland
Titolo Testata:
ONCOGENE
fascicolo: 53, volume: 19, anno: 2000,
pagine: 6122 - 6129
SICI:
0950-9232(200012)19:53<6122:MOAATU>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; ENDOTHELIAL PROGENITOR CELLS; LYMPH-NODE METASTASIS; FACTOR-C EXPRESSION; VEGF-C; TRANSGENIC MICE; IN-VIVO; INTEGRIN ALPHA(V)BETA(3); MONOCLONAL-ANTIBODY; SUPPRESSOR PROTEIN;
Keywords:
breast cancer; metastasis; lymphatic vessels; VEGF; VEGF-C;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Alitalo, K Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, POB 21,Haartmaninkatu 3, FIN-00014 Helsinki, Finland Univ Helsinki POB 21,Haartmaninkatu 3 Helsinki Finland FIN-00014
Citazione:
A. Saaristo et al., "Mechanisms of angiogenesis and their use in the inhibition of tumor growthand metastasis", ONCOGENE, 19(53), 2000, pp. 6122-6129

Abstract

There is a constant requirement for vascular supply in solid tumors. Tumor-associated neovascularization allows the tumor cells to express their critical growth advantage. Axillary lymph node status is the most important prognostic factor in operable breast cancer, and experimental and clinical evidence suggests that the process of metastasis is also angiogenesis-dependent. Various angiogenic growth factors and cytokines induce neovascularization in tumors, namely members of the vascular endothelial growth factor (VEGF) and angiopoietin (Ang) gene families. A strong correlation has been foundbetween VEGF expression and increased tumor microvasculature, malignancy, and metastasis in breast cancer, Anti-angiogenic therapy approaches offer anew promising anti-cancer strategy and a remarkably diverse group of over 20 such drugs is currently undergoing evaluation in clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:46:21