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Titolo:
Recurrent germinoma in the optic nerve: Report of two cases
Autore:
Nakajima, T; Kumabe, T; Jokura, H; Yoshimoto, T;
Indirizzi:
Tohoku Univ, Sch Med, Dept Neurosurg, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
NEUROSURGERY
fascicolo: 1, volume: 48, anno: 2001,
pagine: 214 - 217
SICI:
0148-396X(200101)48:1<214:RGITON>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-CELL TUMORS; TERM FOLLOW-UP; INTRACRANIAL GERMINOMA; RADIATION-THERAPY; SYSTEM GERMINOMA; DOSE RADIATION; CHEMOTHERAPY; IRRADIATION; SURVIVORS; ETOPOSIDE;
Keywords:
dissemination; germinoma; optic nerve; radiochemotherapy; recurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kumabe, T Tohoku Univ, Sch Med, Dept Neurosurg, Aoba Ku, 1-1 Seiryo Machi,Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 , Japan
Citazione:
T. Nakajima et al., "Recurrent germinoma in the optic nerve: Report of two cases", NEUROSURGER, 48(1), 2001, pp. 214-217

Abstract

OBJECTIVE AND IMPORTANCE: Intracranial germinomas often disseminate via the ventricular and subarachnoid pathways, but seeding to the perioptic arachnoid space is extremely unusual. We report two cases of recurrent germinomaseeding in the optic nerve. CLINICAL PRESENTATION: Two men with pure germinoma were initially treated with three cycles of a three-drug regimen of bleomycin, etoposide, and cisplatin, and a complete response was achieved, Patient 1 experienced ventricle wall dissemination 10 months after undergoing the initial treatment and was successfully treated with three cycles of carboplatin and etoposide and then by 24-Gy whole-ventricle radiation. Twelve months later, he complainedof progressive visual acuity loss, and magnetic resonance imaging demonstrated bilateral enhancement of the optic nerves. Patient 2 also experienced ventricle wall dissemination 3 months after undergoing the initial chemotherapy, but he exhibited a complete response after undergoing 24-Gy whole-ventricle radiation. Two years later, he complained of progressive visual acuity toss. Magnetic resonance imaging demonstrated bilateral enhancement of the optic nerves and cerebellar hemispheres. INTERVENTION: None of the locations of recurrence were included in the irradiation field, whereas there was no recurrence within the radiation field. Complete responses were obtained with three cycles of a three-drug regimenof ifosfamide, cisplatin, and etoposide and then by 24-Gy whole-brain radiation that included the bilateral optic nerves. The visual acuity of each patient improved slightly. CONCLUSION: Delayed seeding in the optic nerve may result from germinoma cells that remain dormant, so they cannot be destroyed by chemotherapy regimens alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/18 alle ore 01:23:17