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Titolo:
Influence of smoking, hypertension, and sex on the phenotypic expression of familial intracranial aneurysms in siblings
Autore:
Connolly, ES; Choudhri, TF; Mack, WJ; Mocco, J; Spinks, TJ; Slosberg, J; Lin, T; Huang, J; Solomon, RA;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Dept Neurol Surg, New York, NY 10032 USA Columbia Univ New York NY USA 10032 t Neurol Surg, New York, NY 10032 USA
Titolo Testata:
NEUROSURGERY
fascicolo: 1, volume: 48, anno: 2001,
pagine: 64 - 68
SICI:
0148-396X(200101)48:1<64:IOSHAS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBARACHNOID HEMORRHAGE; IDENTICAL-TWINS; RISK; MANAGEMENT;
Keywords:
aneurysm; familial risk factors; hypertension; intracranial aneurysms; sex; smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Connolly, ES Columbia Univ, Coll Phys & Surg, Dept Neurol Surg, Neurol Inst Room 431,710 W 168th St, New York, NY 10032 USA Columbia Univ Neurol InstRoom 431,710 W 168th St New York NY USA 10032
Citazione:
E.S. Connolly et al., "Influence of smoking, hypertension, and sex on the phenotypic expression of familial intracranial aneurysms in siblings", NEUROSURGER, 48(1), 2001, pp. 64-68

Abstract

OBJECTIVE: To investigate the effects of smoking, hypertension, and sex onthe phenotypic expression of familial intracranial aneurysms (FIAs). METHODS: We retrospectively reviewed the case records of 806 consecutive patients undergoing aneurysm surgery at our institution (1986-1995) and discovered 24 families with at least two affected siblings. Prevalence rates for the smoking, hypertension, and sex risk factors in these nuclear familieswere compared with those of patients with sporadic intracranial aneurysms (SIAs) and population-based control patients. RESULTS: Affected family members with FIAs exhibited prevalence rates of smoking and hypertension (74% and 43%, respectively) that tended to be higher than those of population-based control patients (52% [P < 0.005] and 36% [P = not significant (NS)], respectively) and comparable to those of patients with SIAs (64% [P = NS] and 40% [P = NS], respectively). A positive association existed between FIA formation and female sex but was somewhat less strong than that observed in the SIAs (59% FIAs, 71% SIAs, 50% control patients). In addition, the prevalence rates of smoking, hypertension, and female sex were higher in affected family members with FIAs than in their unaffected siblings (58% [P < 0.05], 28% [P = 0.06], and 39% [P < 0.05], respectively). Individuals in families with expressed FIAs who had high aneurysmalpenetrance had a greater tendency to be smokers, hypertensive, and female (74%, 59%, and 55%, respectively) than did their low-penetrance counterparts (61% [P = 0.1], 27% [P < 0.05], and 45% [P = NS], respectively). CONCLUSION: Together these data suggest that hypertension, smoking, and female sex increase the likelihood that a member of a family with an expressed FIA will have an aneurysm. These observations may prove helpful in guiding the use of screening studies and encouraging education about the potential risks of continued tobacco use and untreated hypertension in this patientcohort.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:14:24