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Titolo:
Patterns of GAP-43 (B-50) expression and accumulation in subchronic acrylamide neurotoxicity
Autore:
Reagan, KE; Jensen, KF; Friedman, MA; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA Nickel Producers Environm Res Assoc, Durham, NC 27713 USA Nickel ProducersEnvironm Res Assoc Durham NC USA 27713 ham, NC 27713 USA US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 & Dev, Res Triangle Pk, NC 27711 USA Univ Med & Dent New Jersey, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 rsey, Newark, NJ 07103 USA
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 27, anno: 2000,
pagine: 199 - 212
SICI:
0893-6609(200011/12)27:3<199:POG(EA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SCIATIC-NERVE; GROWTH-ASSOCIATED PROTEIN; UNMYELINATED AXON SHAFTS; SCHWANN-CELLS; B-50/GROWTH-ASSOCIATED PROTEIN-43; PHOSPHOLIPID-METABOLISM; NEUROFILAMENT PROTEINS; TRANSPORTED PROTEINS; B-50/GAP-43; NEUROPATHY;
Keywords:
peripheral neuropathy, nerve crush; axon; degeneration; regeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 c Biol, Durham, NC 27710 USA
Citazione:
K.E. Reagan et al., "Patterns of GAP-43 (B-50) expression and accumulation in subchronic acrylamide neurotoxicity", NEUROSC R C, 27(3), 2000, pp. 199-212

Abstract

The expression and accumulation of GAP-43 was characterized by immunoblot,immunohistochemistry, and in situ hybridization in the dorsal root gangliaand sciatic nerve of rats exposed to 0.05% acrylamide in drinking water for 14 days. Animals were sacrificed on 2, 10, 14, 21, 28, 35, or 80 days after the initiation of exposure. GAP-43 mRNA expression in the dorsal root ganglia increased at 14 days and GAP-43 protein in sciatic nerve increased at24 days. The peak of GAP-43 expression corresponded to the time of the maximal rate of clinical recovery, consistent with the hypothesis that GAP-43 is involved aspects of neurological recovery in addition to axonal regeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:22:49