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Titolo:
Expression of MAP1a and MAP1b in the ganglionic eminence and the interval capsule of the human fetal brain
Autore:
Ulfig, N; Feldhaus, C; Setzer, M; Bohl, J;
Indirizzi:
Univ Rostock, Dept Anat, Neuroembryon Res Lab, D-18055 Rostock, Germany Univ Rostock Rostock Germany D-18055 n Res Lab, D-18055 Rostock, Germany Univ Frankfurt, Dept Neurosurg, D-60528 Frankfurt, Germany Univ FrankfurtFrankfurt Germany D-60528 urg, D-60528 Frankfurt, Germany Univ Mainz, Dept Neuropathol, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 ept Neuropathol, D-55131 Mainz, Germany
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 38, anno: 2000,
pagine: 397 - 405
SICI:
0168-0102(200012)38:4<397:EOMAMI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE-ASSOCIATED PROTEINS; THALAMIC RETICULAR NUCLEUS; RAT SPINAL-CORD; GROWING AXONS; POPULATION; NEOCORTEX; PATTERNS; REGIONS; NEURONS; ZONE;
Keywords:
axonal guidance; perireticular nucleus; intermediate target; thalamus; reticular nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ulfig, N Univ Rostock, Dept Anat, Neuroembryon Res Lab, Gertrudenstr 9, D-18055 Rostock, Germany Univ Rostock Gertrudenstr 9 Rostock Germany D-18055ock, Germany
Citazione:
N. Ulfig et al., "Expression of MAP1a and MAP1b in the ganglionic eminence and the interval capsule of the human fetal brain", NEUROSCI RE, 38(4), 2000, pp. 397-405

Abstract

The expression of microtubule-associated proteins 1a and 1b (MAP1a and 1b)were investigated in two transient structures, the ganglionic eminence (GE) being a prominent part of the telencephalic proliferative zone and the perireticular nucleus (PR) within the internal capsule (IC). Anti-MAP1a immunolabels PR neurons from 18 weeks of gestation (wg) onwards, whereas anti-MAP1b immunolabels long IC fibers between 18 and 22 wg. MAP1b is further present in thalamic fibers that seem to terminate at the medial margin of the GE, in a moderate number of cells of the GE and its medial extension, the gangliothalamic body (GTB). From 26 to 33 wg MAP1b is expressed in short fiber bundles of the IC, a few MAP1b-positive cells are seen in the GE. MAP1a has so far been described to appear in differentiated neurons and to be related to late developmental events. However, the transient PR being involved in axonal guidance as an intermediate target shows a precocious MAP1a-expression. The MAP1b-finding that thalamocortical fibers accumulate at the GE-margin indicates that this region represents an intermediate target for these fibers. The short MAP1b fiber bundles found in the IC are in accordance with cell culture experiments showing that MAP1b is concentrated in distal parts of outgrowing axons. (C) 2000 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:41:53