Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Environmental familiarization in rats: Differential effects of acute and chronic nicotine
Autore:
Bevins, RA; Koznarova, J; Armiger, TJ;
Indirizzi:
Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 a, Dept Psychol, Lincoln, NE 68588 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 1, volume: 75, anno: 2001,
pagine: 63 - 76
SICI:
1074-7427(200101)75:1<63:EFIRDE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
16-ARM RADIAL MAZE; NUCLEUS-ACCUMBENS; REFERENCE MEMORY; ALZHEIMERS-DISEASE; LOCOMOTOR-ACTIVITY; DOPAMINE RELEASE; WORKING-MEMORY; NOVELTY; ACETYLCHOLINE; RECEPTORS;
Keywords:
acetylcholine; activity; cholinergic; habituation; learning; memory; nicotinic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Bevins, RA Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 chol, Lincoln, NE 68588 USA
Citazione:
R.A. Bevins et al., "Environmental familiarization in rats: Differential effects of acute and chronic nicotine", NEUROBIOL L, 75(1), 2001, pp. 63-76

Abstract

If an environment is familiar, rats will interact more with a novel objectthan if the environment is unfamiliar. In two experiments we used this behavioral tendency to assess the effects of nicotine on environmental familiarization (i.e., an elevated platform). As expected, rats given 2 min of exposure to the platform on 2 consecutive days (familiarization phase) interacted more with a novel object in a subsequent test than rats that had not experienced the platform until the test day. During the familiarization phaseacute pretreatment with nicotine (0.6 and 1.8 mg/kg, subcutaneous) 10 min before platform exposure interfered with familiarization processes, as measured by object interaction on the drug-free test day. Behavioral measures of activity (e.g., turning and midline crosses) eliminated an account based on nicotine-induced motor impairment. Furthermore, this effect of acute nicotine on familiarization was not due to nonspecific effects of nicotine. Controls that received equivalent nicotine exposure temporally separated fromplatform exposure interacted more with the novel object than similarly treated controls that were unfamiliar with the platform on the test day. Interestingly, rats treated once daily with 0.6 mg/kg nicotine for 14 days before the familiarization phase (chronic condition) did not show a decrease in environmental familiarity. This dissociation extends a growing literature finding that the behavioral and neurobiological effects of nicotine differ, in part, after acute and chronic exposure. Indeed, acute nicotine (0.2, 0.6, and 1.2 mg/kg) in the present report consistently decreased the amount oftime spent with one paw on the edge of the platform; chronic nicotine did not affect this behavior, (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:47:24