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Titolo:
Cellular expression of alpha 7 nicotinic acetylcholine receptor protein inthe temporal cortex in Alzheimer's and Parkinson's disease - A stereological approach
Autore:
Banerjee, C; Nyengaard, JR; Wevers, A; de Vos, RAI; Steur, ENHJ; Lindstrom, J; Pilz, K; Nowacki, S; Bloch, W; Schroder, H;
Indirizzi:
Univ Cologne, Dept Anat, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 Dept Anat, D-50924 Cologne, Germany Aarhus Univ, Stereol Res Lab, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C Stereol Res Lab, DK-8000 Aarhus C, Denmark Lab Pathol Oost Nederland, NL-7512 AD Enschede, Netherlands Lab Pathol Oost Nederland Enschede Netherlands NL-7512 AD e, Netherlands Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Neurosci, Philadelphia, PA 19104 USA Med Spectrum Twente, Dept Neurol, NL-7500 KA Enschede, Netherlands Med Spectrum Twente Enschede Netherlands NL-7500 KA nschede, Netherlands
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 6, volume: 7, anno: 2000,
pagine: 666 - 672
SICI:
0969-9961(200012)7:6<666:CEOA7N>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINOCEPTIVE NEURONS; ARBITRARY PARTICLES; FRONTAL-CORTEX; NUMBER; SUBUNITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Banerjee, C Univ Cologne, Dept Anat, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 -50924 Cologne, Germany
Citazione:
C. Banerjee et al., "Cellular expression of alpha 7 nicotinic acetylcholine receptor protein inthe temporal cortex in Alzheimer's and Parkinson's disease - A stereological approach", NEUROBIOL D, 7(6), 2000, pp. 666-672

Abstract

Cognitive deficits in Alzheimer's and Parkinson's disease are closely related to disturbed cholinergic transmission. The decrease of nicotinic acetylcholine receptor protein has been assessed by Western blotting and immunohistochemistry. Stereology, however, has not been used to assess numbers of receptor-expressing human cerebrocortical neurons. Our approach applies a combination of alpha7 subunit-immunohistochemistry with a stereological technique using defined stretches of pial surface as reference standard. The number of alpha7 subunit protein-expressing neurons in the Alzheimer temporal cortices amounted to approximately half of that of controls while numbers in Parkinson patients lay in between. No differences in the total number of neurons were seen. These results corroborate nonstereological studies on Alzheimer cortices and for the first time show a similar decrease in receptorexpression in Parkinson's disease. They provide evidence that not only Alzheimer dementia but also cognitive deficits in Parkinson's disease may be related to decreased nicotinic receptor expression. (C) 2000 Academic Press.

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Documento generato il 28/11/20 alle ore 12:21:22