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Titolo:
A neural model of working memory processes in normal subjects, Parkinson'sdisease and schizophrenia for fMRI design and predictions
Autore:
Monchi, O; Taylor, JG; Dagher, A;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Mcconnell Braining Imaging Ctr, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Ctr, Montreal, PQ H3A 2B4, Canada Univ London Kings Coll, Dept Math, Ctr Neural Network, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
NEURAL NETWORKS
fascicolo: 8-9, volume: 13, anno: 2000,
pagine: 953 - 973
SICI:
0893-6080(200010/11)13:8-9<953:ANMOWM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR CINGULATE CORTEX; POSITRON EMISSION TOMOGRAPHY; CARD SORTING TEST; BASAL GANGLIA; PREFRONTAL CORTEX; COGNITIVE FUNCTIONS; FRONTAL-CORTEX; RHESUS-MONKEY; ACTIVATION; DYSFUNCTION;
Keywords:
computational neuroscience; functional magnetic resonance imaging; working memory; Parkinson's disease; schizophrenia; prefrontal cortex; basal ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Monchi, O McGill Univ, Montreal Neurol Inst, Mcconnell Braining Imaging Ctr, Webster2B,3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ Webster2B,3801 Univ St Montreal PQ Canada H3A 2B4 a
Citazione:
O. Monchi et al., "A neural model of working memory processes in normal subjects, Parkinson'sdisease and schizophrenia for fMRI design and predictions", NEURAL NETW, 13(8-9), 2000, pp. 953-973

Abstract

A computational model was previously developed to investigate the role of parallel basal ganglia-thalamocortical loops in solving tasks that rely on working memory. Different lesions are applied to the model in order to investigate the working memory deficits observed in Parkinson's disease and schizophrenia. The simulations predict that the working memory deficits observed in Parkinson's disease result from a local dysfunction within the brain due to a problem in the disinhibitory process arising from the basal ganglia. They also predict that the working memory deficits observed in schizophrenia involve many cortical and subcortical areas and result from a problem in selecting items in working memory which are stored in basal ganglia-thalamocortical loops. The simulations predict the temporal unfolding of neuronal activity in different brain regions, both in the normal case and in the two disease states. A specific event-related functional magnetic resonance imaging study was elaborated to test some of those predictions. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:42:13