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Titolo:
Unravelling the pharmacological profile of the canine external carotid vasodilator '5-HT1-like" receptors: coexistence of sympatho-inhibitory 5-HT1B and postjunctional 5-HT7 receptors
Autore:
Villalon, CM; Sanchez-Lopez, A; Centurion, D; Saxena, PR;
Indirizzi:
IPN, CINVESTAV, Dept Farmacol, Mexico City, DF, Mexico IPN Mexico City DFMexico VESTAV, Dept Farmacol, Mexico City, DF, Mexico Erasmus Univ, Fac Med & Hlth Sci, Dept Pharmacol, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 1, volume: 363, anno: 2001,
pagine: 73 - 80
SICI:
0028-1298(200101)363:1<73:UTPPOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAGOSYMPATHECTOMIZED DOGS; CLOSE RESEMBLANCE; BLOOD-FLOW; 5-HYDROXYTRYPTAMINE; VASOCONSTRICTION; RESPONSES; SEROTONIN; INCREASE; SUBTYPE; PIG;
Keywords:
5-HT1B receptor; 5-HT7 receptor; BRL15572; canine external carotid vasodilatation; mesulergine; SB224289; sumatriptan; PNU-142633;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Villalon, CM IPN, CINVESTAV, Dept Farmacol, Czda de los Tenorios 235,Col Granjas Coapa,Mexico City, DF, Mexico IPN Czda de los Tenorios 235,Col Granjas Coapa Mexico City DF Mexico
Citazione:
C.M. Villalon et al., "Unravelling the pharmacological profile of the canine external carotid vasodilator '5-HT1-like" receptors: coexistence of sympatho-inhibitory 5-HT1B and postjunctional 5-HT7 receptors", N-S ARCH PH, 363(1), 2001, pp. 73-80

Abstract

It has been suggested that the external carotid vasodilatation produced byserotonin (5-hydroxytryptamine; 5-HT) in anaesthetised dogs with intact vagosympathetic trunks is mediated by sympatho-inhibitory '5-HT1D' receptors and musculotropic '5-HT1-like' receptors. The present study has re-analysedthis suggestion with regard to the classification schemes recently proposed by the NC-IUPHAR subcommittee on 5-HT receptors. In pentobarbital-anaesthetised dogs with intact vagosympathetic trunks, 1-min intracarotid (i.c.) infusions of 5-carboxamidotryptamine (5-CT; 0.01-0.3 mug/min), 5-HT (0.3-30 mug/min), 5-methoxytryptamine (5-MeO-T; 1-100 mug/min) or sumatriptan (1-100 mug/min) dose-dependently increased the external carotid blood flow without affecting blood pressure or heart rate. The selective 5-HT1D receptor agonist, PNU-142633 (1-1000 mug/min), was essentially inactive. After mesulergine (300 mug/kg, i.v.), an antagonist at cardiovascular 5-HT7 receptors, the above responses to 5-HT, 5-CT and 5-MeO-T were blocked, whilst those to sumatriptan remained unaffected. In contrast, after the 5-HT1B/1D receptor antagonist, GR127935 (10 mug/kg, i.v.), the responses to 5-MT, 5-CT and 5-MeO-T were not affected, but those to sumatriptan were abolished. Furthermore, after the selective 5-HT1B receptor antagonist, SB224289 (300 mug/kg, i.v.), the responses to 5-MT, 5-CT and 5-MeO-T were significantly enhanced, whereas those to sumatriptan were abolished. Interestingly, the responses toall these agonists remained unmodified after the selective 5-HT1D receptorantagonist, BRL15572 (300 mug/kg, i.v.). The above results suggest that the '5-HT1-like' receptors, which mediate canine external carotid vasodilatation, display the pharmacological profile of sympatho-inhibitory 5-HT1B receptors and musculotropic 5-HT7 receptors, and confirm the existence of vasoconstrictor 5-HT1B receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:22:42