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Titolo:
Neurotrophins as synaptic modulators
Autore:
Poo, MM;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 1, volume: 2, anno: 2001,
pagine: 24 - 32
SICI:
1471-0048(200101)2:1<24:NASM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; LONG-TERM POTENTIATION; CULTURED HIPPOCAMPAL-NEURONS; RAT VISUAL-CORTEX; DEVELOPING NEUROMUSCULAR SYNAPSES; RETROGRADE AXONAL-TRANSPORT; LOCAL PROTEIN-SYNTHESIS; BDNF KNOCKOUT MICE; MESSENGER-RNA; SYMPATHETIC NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Poo, MM Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 229 Stanley Hall Berkeley CA USA 94720 720 USA
Citazione:
M.M. Poo, "Neurotrophins as synaptic modulators", NAT REV NEU, 2(1), 2001, pp. 24-32

Abstract

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of neurons has been well described. More recent evidence indicates that neurotrophins may also act as synaptic modulators. Here, Ireview the evidence that synaptic activity regulates the synthesis, secretion and action of neurotrophins, which can in turn induce immediate changesin synaptic efficacy and morphology. By this account, neurotrophins may participate in activity dependent synaptic plasticity linking synaptic activity with long-term functional and structural modification of synaptic connections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:08:40