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Titolo:
Association of the Apolipoprotein E gene with age-related macular degeneration: Possible effect modification by family history, age, and gender
Autore:
Schmidt, S; Saunders, AM; De la Paz, M; Postel, EA; Heinis, RM; Agarwal, A; Scott, WK; Gilbert, JR; McDowell, JG; Bazyk, A; Gass, JDM; Haines, JL; Pericak-Vance, MA;
Indirizzi:
Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med, Ctr Human Genet, Durham, NC 27710 USA Duke Univ, Med Ctr, Ctr Eye, Durham, NC 27710 USA Duke Univ Durham NC USA27710 niv, Med Ctr, Ctr Eye, Durham, NC 27710 USA Duke Univ, Med Ctr, Div Neurol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 , Med Ctr, Div Neurol, Durham, NC 27710 USA Vanderbilt Univ, Med Ctr, Dept Ophthalmol & Visual Sci, Nashville, TN USA Vanderbilt Univ Nashville TN USA thalmol & Visual Sci, Nashville, TN USA Vanderbilt Univ, Med Ctr, Program Human Genet, Nashville, TN USA Vanderbilt Univ Nashville TN USA Program Human Genet, Nashville, TN USA
Titolo Testata:
MOLECULAR VISION
fascicolo: 35, volume: 6, anno: 2000,
pagine: 287 - 293
SICI:
1090-0535(200012)6:35<287:AOTAEG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPORADIC ALZHEIMERS-DISEASE; CASSETTE TRANSPORTER GENE; BEAVER DAM EYE; STARGARDT-DISEASE; TYPE-4 ALLELE; ABCR; BINDING; RISK; MACULOPATHY; EPSILON-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Pericak-Vance, MA Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Box 3445,Durham, NC 27710 USA Duke Univ Box 3445 Durham NC USA 27710 ham, NC 27710 USA
Citazione:
S. Schmidt et al., "Association of the Apolipoprotein E gene with age-related macular degeneration: Possible effect modification by family history, age, and gender", MOL VIS, 6(35), 2000, pp. 287-293

Abstract

Purpose: Age-related macular degeneration (AMD) is a complex disorder affecting older adults in which genetic factors are likely to play a role. It has been previously suggested that the epsilon4 allele of the apolipoproteinE (APOE) gene may have a protective effect on AMD risk and that the epsilon2 allele may increase disease risk. The purpose of our study was to examine whether an independent data set would support the proposed role of APOE in AMD etiology. Methods: We compared AMD cases (n=230) to controls (n=372) with respect toAPOE genotypes using chi (2) tests and logistic regression analysis. We also conducted separate analyses for familial (n=129) and sporadic (n=101) AMD cases since these groups may have a different disease etiology. Results: We did not find evidence for the risk-increasing effect attributed to the epsilon2 allele in either familial or sporadic AMD. No evidence for a protective effect of the epsilon4 allele was obtained for sporadic AMD. The age- and sex-adjusted odds ratio (OR) for epsilon4 carriers among familial AMD cases compared to controls was 0.66 (95% confidence interval: 0.38-1.12, p=0.13). In the subgroup of individuals younger than 70 years of age, an OR of 0.24 (95% confidence interval: 0.08-0.72, p=0.004) was obtained. Conclusions: Our data modestly support a protective effect of the APOE-epsilon4 allele on AMD risk, but emphasize the need to investigate more thoroughly whether the effect could be restricted to cases with a family history of AMD and whether it varies across age and sex groups.

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Documento generato il 04/07/20 alle ore 16:53:08