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Titolo:
Nucleotide variation at the yellow gene region is not reduced in Drosophila subobscura: A study in relation to chromosomal polymorphism
Autore:
Munte, A; Aguade, M; Segarra, C;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 12, volume: 17, anno: 2000,
pagine: 1942 - 1955
SICI:
0737-4038(200012)17:12<1942:NVATYG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR POPULATION-GENETICS; ACHAETE-SCUTE REGION; DNA POLYMORPHISM; OBSCURA GROUP; X-CHROMOSOME; TRANSPOSABLE ELEMENT; NATURAL-POPULATIONS; REGULATORY ELEMENTS; CENTROMERIC REGION; MELANOGASTER;
Keywords:
Drosophila subobscura; yellow gene; nucleotide polymorphism; X chromosome; inversion polymorphism; recombination rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Segarra, C Univ Barcelona, Fac Biol, Dept Genet, Diagonal 645, E-08071 Barcelona, Spain Univ Barcelona Diagonal 645 Barcelona Spain E-08071 ona, Spain
Citazione:
A. Munte et al., "Nucleotide variation at the yellow gene region is not reduced in Drosophila subobscura: A study in relation to chromosomal polymorphism", MOL BIOL EV, 17(12), 2000, pp. 1942-1955

Abstract

In contrast to Drosophila melanogaster and Drosophila simulans, the yellow(y) gene region of Drosophila subobscura is not located in a region with astrong reduction in recombination. In addition, this gene maps very close to the breakpoints of different inversions that segregate as polymorphic innatural populations of D. subobscura. Therefore, levels of variation at the y gene region in this species relative to those found in D. melanogaster and D. simulans may be affected not only by the change in the recombinational environment, but also by the presence of inversion polymorphism. To further investigate these aspects, an approximately 5.4-kb region of the A (=X)chromosome including the y gene was sequenced in 25 lines of D. subobscuraand in the closely related species Drosophila madeirensis and Drosophila guanche. The D. subobscura lines studied differed in their A-chromosomal arrangements, A(st), A(2), and A(1). Unlike in D. melanogaster and D. simulans, levels of variation at the y gene region of D. subobscura are not reducedrelative to those found at other genomic regions in the same species (rp49, Acp70A, and Acph-1). This result supports the effect of the change in therecombinational environment of a particular gene on the level of neutral variation. In addition, nucleotide variation is affected by chromosomal polymorphism. A strong genetic differentiation is detected between the A(1) arrangement and either A(st) or A(2), but not between A(st) and A(2). This result is consistent with the location of the y gene relative to the breakpoints of inversions A(1) and A(2). In addition, the pattern of nucleotide polymorphism in A(st)+A(2) and A(1) seems to point out that variation at the y gene region within these chromosomal classes is in the phase transient to equilibrium. The estimated ages of these arrangements assuming a star genealogy indicate that their origin cannot predate the D. madeirensis split. Therefore, the present results are consistent with a chromosomal phylogeny where Am-1, which is an arrangement present in D. madeirensis but absent in current populations of D. subobscura, would be the ancestral arrangement.

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Documento generato il 21/09/20 alle ore 08:24:35