Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists
Autore:
Dionne, MS; Skarnes, WC; Harland, RM;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Div Genet & Dev, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 t & Dev, Berkeley, CA 94720 USA
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 636 - 643
SICI:
0270-7306(200101)21:2<636:MAAODT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-BETA; SECRETED PROTEINS; XENOPUS EMBRYOS; SPINAL-CORD; EXPRESSION; GENE; BMP; CERBERUS; INDUCER; SUPERFAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Harland, RM Univ Calif Berkeley, Dept Mol & Cell Biol, Div Genet & Dev, 401 Barker Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 401 Barker Hall Berkeley CA USA 94720 USA
Citazione:
M.S. Dionne et al., "Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists", MOL CELL B, 21(2), 2001, pp. 636-643

Abstract

The Dan family of transforming growth factor beta antagonists is a large, evolutionarily conserved family of proteins. Little is known about either the specificity of these antagonists or the biological roles of these proteins. We have characterized Dan, the founding member of this family, with regard to both its biochemical specificity and its biological roles. Although DAN is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting thatDAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo. Intriguingly, in developing neurons, Dan mRNA was localized to axons, suggesting apotential role for the DAN protein in axonal outgrowth or guidance. Mice lacking Dan activity were generated by gene targeting and displayed subtle, background-dependent defects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:27:09