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Titolo:
Evaluation of catecholamine metabolites, mIBG scan, and bone marrow cytology as response markers in stage 4 neuroblastoma
Autore:
Hero, B; Hunneman, DH; Gahr, M; Berthold, F;
Indirizzi:
Univ Cologne, Childrens Hosp, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 rens Hosp, D-50924 Cologne, Germany Univ Gottingen, Childrens Hosp, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 Hosp, D-3400 Gottingen, Germany Univ Dresden, Childrens Hosp, Dresden, Germany Univ Dresden Dresden Germany Dresden, Childrens Hosp, Dresden, Germany
Titolo Testata:
MEDICAL AND PEDIATRIC ONCOLOGY
fascicolo: 1, volume: 36, anno: 2001,
pagine: 220 - 223
SICI:
0098-1532(200101)36:1<220:EOCMMS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA;
Keywords:
disseminated neuroblastoma; response to therapy; mIBG scan; bone marrow cytology; catecholamine metabolites; vanilmandelic acid; homovanillic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Hero, B Univ Cologne, Childrens Hosp, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924 rmany
Citazione:
B. Hero et al., "Evaluation of catecholamine metabolites, mIBG scan, and bone marrow cytology as response markers in stage 4 neuroblastoma", MED PED ONC, 36(1), 2001, pp. 220-223

Abstract

Background. The early biological response has been proved an excellent predictor in acute lymphoblastic leukemia and nephroblastoma. We asked whethercatecholamine metabolites, mIBG scan, and bone marrow evaluation might be relevant response markers in disseminated neuroblastoma. Procedure. Three hundred sixty-seven unselected stage 4 neuroblastoma patients treated according the German cooperative trial NB90 were entered into the study. Catecholamine plasma and urine levels were centrally determined by gas chromatography/ mass spectrometry. Bone marrow cytology and mIBG scans were evaluated by local investigators. Results. Ar diagnosis, mIBG scan was positive in 306patients (92%), borderline in seven patients (2%), and negative in 19 patients (6%). Bone marrow aspirates were cytologically positive in 292 patients (84%) and negative in 57 patients (16%). Plasma catecholamine levels wereelevated in 79% (206 of 260 patients.), urinary levers in 92% (307 of 338 patients). The outcome of patients with normalized mIBG scan after four courses of chemotherapy [5 year EFS (event free survival) 0.22 +/- 0.071 was not superior to the outcome of patients with still abnormal uptake (5 year EFS 0.30 +/- 0.05). The event free survival of patients with still positive bone marrow aspirates after four courses (0.16 +/- 0.06) was inferior to the EFS of patients with negative bone marrow aspirates (0.26 +/- 0.04, P = 0.0054). Urinary catecholamine normalization after four cycles of chemotherapy (5 year EFS 0.35 +/- 0.06 Versus 0.26 +/- 0.10) had no influence on outcome, whereas plasma catecholamine normalization after the first (5 year EFS0.40 +/- 0.09 versus 0.14 +/- 0.07, P = 0.0364) or the fourth cycle (5 year EFS 0.35 +/- 0.06 versus 0.26 +/- 0.10, P = 0.0242) indicated a better outcome. Conclusions. These data show that serial plasma catecholamine levelsand bone marrow aspirates in the course of the disease are useful toots inpredicting outcome. Med. Pediatr. Oncol. 36:220-223, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:28:50