Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system
Autore:
Kusumi, K; Dunwoodie, SL; Krumlauf, R;
Indirizzi:
Natl Inst Med Res, Div Dev Neurobiol, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA robiol, London NW7 1AA, England Natl Inst Med Res, Div Mammalian Dev, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA an Dev, London NW7 1AA, England
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1, volume: 100, anno: 2001,
pagine: 141 - 144
SICI:
0925-4773(200101)100:1<141:DEPOTP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-HOMOLOG; NOTCH; NEUROGENESIS; HOXB-1; LIGAND; MICE;
Keywords:
Notch signaling; Dll3; pudgy; spondylocostal dysostosis; neural patterning; mouse mutant; neurogenesis; hindbrain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kusumi, K Stowers Inst Med Res, E 50th St, Kansas City, MO 64110 USA Stowers Inst Med Res E 50th St Kansas City MO USA 64110 4110 USA
Citazione:
K. Kusumi et al., "Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system", MECH DEVEL, 100(1), 2001, pp. 141-144

Abstract

Defects in the Notch pathway ligand Dll3 have been identified in the mousepudgy (Dll3(pu)) and human spondylocostal dysostosis (SD, MIM 277300) mutations. Although these mutations are primarily associated with segmental defects in the axial skeleton and semitic patterning, they also exhibit cranial neurological defects. Therefore we have looked at the expression of Dll3 in the developing mouse nervous system. The expression of Notch ligands andreceptors shares common features at 10.75 dpc in the rhombic lips and dorsal hindbrain. Temporal analysis of Dll3 expression from 9.0 to 11.0 dpc reveals that it is strongly expressed in laminar columns linked with regions of neuronal differentiation and hindbrain segmentation. Transverse sections show that Dll3 is expressed in territories where commissural neurons are formed. We have also looked at neuronal patterning in the mid-hindbrain region in Dll3(pu) mutants. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:31:05