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Titolo:
The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta
Autore:
Verhaagh, S; Barlow, DP; Zwart, R;
Indirizzi:
Netherlands Canc Inst, Dept Mol Genet, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1, volume: 100, anno: 2001,
pagine: 127 - 130
SICI:
0925-4773(200101)100:1<127:TEMTSC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER; IN-VIVO; EXPRESSION; CLONING; BRAIN; OCT3; RNA;
Keywords:
placenta; catecholamine clearance; Orct3; Slc22a3; EMT; mouse; organic cation transporter; extraneuronal monoamine transporter; uptake(2); Net; Sert; Maoa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Barlow, DP OAW, Inst Mol Biol, Billrothstr 11, A-5020 Salzburg, Austria OAW Billrothstr 11 Salzburg Austria A-5020 0 Salzburg, Austria
Citazione:
S. Verhaagh et al., "The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta", MECH DEVEL, 100(1), 2001, pp. 127-130

Abstract

Monoamine clearance is a combined function of uptake mechanisms in the plasma membrane with intracellular metabolizing enzymes. Two different uptake mechanisms have been described. Uptake(1) is located in presynaptic neurones, whereas uptake(2) is extraneuronal. Recently, the Slc22a3/Orct3 gene wasidentified as the extraneuronal monoamine transporter. In mouse embryonic development Orct3 expression is restricted to the placenta, which is also asite of expression of neuronal transporters. We have used RNA blots and insitu hybridization to examine the expression of Orct3 and other members ofthe monoamine uptake and metabolizing pathways in mouse placenta. The results show that Orct3 expression overlaps that of the monoamine metabolizing enzyme Maoa in the labyrinth layer of the placenta with an expression pattern distinct from that of the neuronal transporters Slc6a2/Net and Slc6a4/Sert. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:34:02