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Titolo:
Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain
Autore:
Vetter, K; Wurst, W;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany GSF, Res Ctr Environm & Hlth, Inst Mammalian Genet, D-85764 Neuherberg, Germany GSF Neuherberg Germany D-85764 malian Genet, D-85764 Neuherberg, Germany
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1, volume: 100, anno: 2001,
pagine: 123 - 125
SICI:
0925-4773(200101)100:1<123:EOANMG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Keywords:
bFGF; cranial nerves; development; eye; FGF2; hippocampus; nervous system; olfactory bulb; purkinje cells; Zic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
4
Recensione:
Indirizzi per estratti:
Indirizzo: Vetter, K Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2-10 Munich Germany D-80804
Citazione:
K. Vetter e W. Wurst, "Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain", MECH DEVEL, 100(1), 2001, pp. 123-125

Abstract

Using an induction gene trap approach with bFGF, we identified a novel mouse gene mbFZb (mouse basic FGF repressed, putative Zic binding protein). Itshows high homology to a putative Zic3 binding protein in Xenopus (AF129131). We used the in situ hybridization technique on sections to analyze the expression pattern of mbFZb during embryonic development in the mouse. FromE9.5 onwards it is expressed mainly in the developing nervous system, withhigh levels of expression in the proliferating neuroepithel of the brain and the neural tube, the ganglia of the cranial nerves V, VII, VD[I, IX and X and the dorsal root ganglia. MbFZbtranscript can also be detected in the developing eye and the brown fat. In the adult brain strong expression is restricted to the olfactory bulb, the hippocampus, the piriform cortex and the Purkinje cells of the cerebellum. On the cellular level the mbFZb/GFP fusion protein is localized in vesicular structures in the cytoplasm. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:58:09