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Titolo:
Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI: (dGEMRIC) for clinical evaluation of articular cartilage
Autore:
Burstein, D; Velyvis, J; Scott, KT; Stock, KW; Kim, YJ; Jaramillo, D; Boutin, RD; Gray, ML;
Indirizzi:
Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 r, Boston, MA 02215 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 1, volume: 45, anno: 2001,
pagine: 36 - 41
SICI:
0740-3194(200101)45:1<36:PIFDGM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GD-DTPA; GLYCOSAMINOGLYCAN;
Keywords:
magnetic resonance imaging; cartilage; contrast; glycosaminoglycans; gadolinium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Burstein, D Beth Israel Deaconess Med Ctr, DA-705330 Brookline Ave, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr DA-705330 Brookline Ave BostonMA USA 02215
Citazione:
D. Burstein et al., "Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI: (dGEMRIC) for clinical evaluation of articular cartilage", MAGN RES M, 45(1), 2001, pp. 36-41

Abstract

Biochemical and histologic data have validated the technique of delayed gadolinium-enhanced MRI, in which the T-1 values of cartilage after penetration of Gd(DTPA)(2-) allow assessment of the glycosaminoglycan (GAG) component of articular cartilage. This work describes the factors that have been found to be important for the practical implementation of the technique: 1) Exercise immediately after intravenous contrast administration was necessaryfor effective penetration of the contrast into the articular cartilage; 2)double-dose contrast was better than single-dose; 3) after contrast administration, a time window of 30-90 min for the hip, and 2-3 hr for all compartments of the knee proved to be appropriate for assessing articular cartilage; and 4) in some cases of hypointensities in the subchondral patellar bone, decreased penetration of the contrast agent into cartilage from bone wasfound. With the protocol described, ROIs on T-1 images were reproducible within 15% on two separate imaging sessions, and initial clinical studies demonstrated the possible applications of the technique. Magn Reson Med 45:36-41, 2001, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:49:55