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Titolo:
Evidence for a nucleus accumbens CCK2 receptor regulation of rat ventral pallidal GABA levels - A dual probe microdialysis study
Autore:
Ferraro, L; OConnor, WT; Glennon, J; Tomasini, MC; Bebe, BW; Tanganelli, S; Antonelli, T;
Indirizzi:
Univ Ferrara, Pharmacol Sect, Dept Clin & Expt Med, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 in & Expt Med, I-44100 Ferrara, Italy Univ Coll Dublin, Conway Inst Biomol & Biochem Res, Dept Human Anat & Physiol, Dublin 2, Ireland Univ Coll Dublin Dublin Ireland 2 uman Anat & Physiol, Dublin 2, Ireland
Titolo Testata:
LIFE SCIENCES
fascicolo: 5, volume: 68, anno: 2000,
pagine: 483 - 496
SICI:
0024-3205(200012)68:5<483:EFANAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; EXTRACELLULAR GABA; B RECEPTOR; IN-VIVO; CHOLECYSTOKININ; DOPAMINE; RELEASE; ANXIETY; ANTAGONIST; NEURONS;
Keywords:
CCK-8S; PD134308; L-364,718; tetrodotoxin; local perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ferraro, L Univ Ferrara, Pharmacol Sect, Dept Clin & Expt Med, Via FossatoMortara 17-19, I-44100 Ferrara, Italy Univ Ferrara Via Fossato Mortara 17-19 Ferrara Italy I-44100 y
Citazione:
L. Ferraro et al., "Evidence for a nucleus accumbens CCK2 receptor regulation of rat ventral pallidal GABA levels - A dual probe microdialysis study", LIFE SCI, 68(5), 2000, pp. 483-496

Abstract

We employed dual probe microdialysis in the nucleus accumbens and ipsilateral ventral pallidum of the halothane anaesthetized rat to investigate the effect of intra-accumbens perfusion with the sulphated octapeptide cholecystokinin (CCK-8S, 10-1000 nM, 60 min) alone and in the presence of the selective CCK1 and CCK2 receptor antagonists L-364,718 (10 and 100 nM) and PD134308 (10 nM), tetrodotoxin (TTX, 1000 nM) and the GABA, receptor antagonist bicuculline (1000 nM),on dialysate GABA levels in the ventral pallidum. Intra-accumbens perfusion with the 100 and 1000 nM concentration of CCK-8S wasassociated with a significant decrease (-16 +/- 3% and -23 +/- 3% vs basal, respectively) in ventral pallidum GABA levels. The CCK-8S (1000 nM) induced decrease in ventral pallidal dialysate GABA levels was abolished when PDI34308, TTX and bicuculline, but not L-364,718, were included into the perfusion medium of the accumbens probe. The data indicate that nucleus accumbens CCK-8S exerts a CCK2 receptor mediated inhibition of ventral pallidal GABA levers. Furthermore, the TTX and bicuculline sensitivity of this effect suggests that this is possibly mediated via CCK2 receptors probably locatedon local GABA interneurons. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:12:47