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Titolo:
Vomiting and gastric motility in infants with cow's milk allergy
Autore:
Ravelli, AM; Tobanelli, P; Volpi, S; Ugazio, AG;
Indirizzi:
Univ Brescia, Spedali Civili, Gastrointestinal Pathophysiol Serv, Dept Pediat, I-25123 Brescia, Italy Univ Brescia Brescia Italy I-25123 , Dept Pediat, I-25123 Brescia, Italy
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 1, volume: 32, anno: 2001,
pagine: 59 - 64
SICI:
0277-2116(200101)32:1<59:VAGMII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROESOPHAGEAL REFLUX; EOSINOPHILIC ESOPHAGITIS; CHILDREN; DISORDERS;
Keywords:
cow's milk protein allergy; electrical impedance tomography; electrogastrography; gastroesophageal reflux; vomiting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ravelli, AM Univ Brescia, Spedali Civili, Gastrointestinal Pathophysiol Serv, Dept Pediat, I-25123 Brescia, Italy Univ Brescia Brescia Italy I-25123 t, I-25123 Brescia, Italy
Citazione:
A.M. Ravelli et al., "Vomiting and gastric motility in infants with cow's milk allergy", J PED GASTR, 32(1), 2001, pp. 59-64

Abstract

Background: Regurgitation and vomiting are common manifestations of cow's milk protein allergy (CMPA) in infants and are usually ascribed to gastroesophageal reflux (GER). Gastric anaphylaxis can induce antral dysmotility inthe rat, and therefore the hypothesis for the current study was that cow'smilk in sensitized infants may impair antral motility, thereby promoting GER and reflex vomiting. Methods: Seven vomiting infants with CMPA and nine with primary GER underwent a challenge with cow's milk formula. Electrogastrography (EGG) was usedto measure the spectral Frequency (bradygastria = 1.5-2.4 cycles per minute [cpm], normogastria = 2.5-3.9 cpm, tachygastria = 4.0-9.0 cpm) and the postprandial-to-fasting power ratio of gastric electrical activity, whereas gastric half-emptying time (T 1/2) was measured by electrical impedance tomography (EIT). Results: In CMPA and GER. respectively, during fasting, the Frequency distribution (mean +/- SD) of the EGG was as follows: normogastria 47.9% +/- 12.5% versus 52.2% +/- 9.8%, bradygastria 24.1% +/- 5.7% versus 22.8% +/- 8.3%, and tachygastria 28.0% +/- 8.5% versus 25.0% +/- 8.3%. In contrast, after the cow's milk challenge, the difference between the two groups was statistically significant: normogastria 33.1% +/- 8.8% versus 70.6% +/- 8.6% (P < 0.0001), bradygastria 38.0% +/- 15.5% versus 15.7% +/- 5.2% (P = 0.002), and tachygastria 28.9% +/- 10.6% versus 13.4% +/- 4.6% (P = 0.001. The postprandial/ fasting power ratio (mean +/- SD) was 3.2 +/- 1.9 in CMPA and 8.1+/- 2.1 in GER (P < 0.0001). Gastric T 1/2 (mean +/- SD) of the cow's milkmeal was 89.0 +/- 26.3 minutes versus 54.0 +/- 12.6 minutes (P = 0.003). In infants with GER all EGG parameters and gastric T 1/2 were similar to that in 10 healthy control infants. Conclusions: In sensitized infants, cow's milk induces severe gastric dysrhythmia and delayed gastric emptying, which in turn may exacerbate GER and induce reflex vomiting. Electrogastrography and EIT can be useful in the assessment of vomiting, GER, and CMPA in infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 11:49:37