Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea
Autore:
Sarker, SA; Casswall, TH; Juneja, YR; Hoq, E; Hossain, I; Fuchs, GJ; Hammarstrom, L;
Indirizzi:
Ctr Hlth & Populat Res, ICDDRB, Div Clin Sci, Dhaka 1212, Bangladesh Ctr Hlth & Populat Res Dhaka Bangladesh 1212 Sci, Dhaka 1212, Bangladesh Huddinge Univ Hosp, Karolinska Inst, Dept Immunol Microbiol Pathol & Infect Dis, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden hol & Infect Dis, Stockholm, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Clin Sci, Div Pediat, Stockholm,Sweden Huddinge Univ Hosp Stockholm Sweden n Sci, Div Pediat, Stockholm,Sweden Taiyo Kagaku Co Ltd, Nutr Foods Div, Yokkaichi, Japan Taiyo Kagaku Co LtdYokkaichi Japan d, Nutr Foods Div, Yokkaichi, Japan
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 1, volume: 32, anno: 2001,
pagine: 19 - 25
SICI:
0277-2116(200101)32:1<19:RPCTOH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE-IMMUNIZATION; STREPTOCOCCUS-MUTANS; BOVINE ROTAVIRUS; ESCHERICHIA-COLI; DENTAL-CARIES; ANTIBODY IGY; PROTECTION; GASTROENTERITIS; VACCINE; INTUSSUSCEPTION;
Keywords:
diarrhea; egg yolk immunoglobulin; immunoglobulin; rotavirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sarker, SA Ctr Hlth & Populat Res, ICDDRB, Div Clin Sci, Dhaka 1212, Bangladesh Ctr Hlth & Populat Res Dhaka Bangladesh 1212 1212, Bangladesh
Citazione:
S.A. Sarker et al., "Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea", J PED GASTR, 32(1), 2001, pp. 19-25

Abstract

Background: Hyperimmunized bovine colostrum containing antibodies has beenshown to be effective in the treatment of rotavirus diarrhea. Antibodies derived from eggs of immunized hens may be a less expensive and more practical alternative. In this study, children with proven rotavirus diarrhea weretreated with immunoglobulin extracted from eggs of chicken immunized with human rotavirus strains. Methods: In a randomized, double-blind study, 79 children with known rotavirus diarrhea were assigned to receive either 10 g hyperimmune egg yolk (HEY) daily in four equally divided doses for 4 days (HEY group) or a similar preparation obtained from nonimmunized chicken (placebo group). The daily stool frequency and amount, oral rehydration solution (ORS) intake, and presence of rotavirus in the stool were monitored for 4 days. Results: In the HEY-treated group. there was significant reduction in stool output (in grams per kilogram per day; HEY vs. placebo; 87 +/- 59 vs. 120+/- 75, P = 0.03), and significant reduction of ORS intake tin millilitersper kilogram per day) (HEY vs. placebo; 84 +/- 46 vs. 122 +/- 72, P = 0.008) on day 1 and clearance of virus on day 4 (HEY vs. placebo; 73% vs. 36%, P = 0.02). There was, however, no difference in diarrheal duration between the groups. Conclusions: Treatment with HEY against four human rotavirus strains resulted in modest improvement of diarrhea associated with earlier clearance of rotavirus from stools. These results indicate an encouraging role of HEY inthe treatment of rotavirus-induced diarrhea in children. Further studies are needed to optimize the dose and neutralization titer and thus improve the efficacy of egg yolk immunoglobulin IgY derived from immunized hens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:06:46