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Titolo:
Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury
Autore:
Herrmann, M; Curio, N; Jost, S; Grubich, C; Ebert, AD; Fork, ML; Synowitz, H;
Indirizzi:
Otto von Guericke Univ, Fac Med, Div Neuropsychol & Behav Neurol, D-39120 Magdeburg, Germany Otto von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Hanse Inst Adv Study, Dept Neurol 2, Bremen, Germany Hanse Inst Adv StudyBremen Germany udy, Dept Neurol 2, Bremen, Germany Hanse Inst Adv Study, Dept Neurosurg, Bremen, Germany Hanse Inst Adv Study Bremen Germany dy, Dept Neurosurg, Bremen, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 1, volume: 70, anno: 2001,
pagine: 95 - 100
SICI:
0022-3050(200101)70:1<95:ROBMOD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEAD-INJURY; PROTEIN S-100; COMPUTED-TOMOGRAPHY; CELL-DEATH; SERUM; ENOLASE; ASTROCYTES; SCALE;
Keywords:
traumatic brain injury; neuron-specific enolase; protein S-100B; neuropsychology; outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Herrmann, M Otto von Guericke Univ, Fac Med, Div Neuropsychol & Behav Neurol, Leipzigerstr 44, D-39120 Magdeburg, Germany Otto von Guericke Univ Leipzigerstr 44 Magdeburg Germany D-39120
Citazione:
M. Herrmann et al., "Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury", J NE NE PSY, 70(1), 2001, pp. 95-100

Abstract

Objectives-The present study aimed at the analysis of release patterns of neurobiochemical markers of brain damage (neuron specific enolase (NSE) andprotein S-100B) in patients with traumatic brain injury and their predictive value with respect to the short and long term neuropsychological outcome. Methods-Serial NSE and S-100B concentrations were analysed in blood samples taken at the first, second, and third day after traumatic brain injury. In 69 patients who fulfilled the inclusion criteria (no history of neurological or psychiatric disorder or alcohol or drug dependency, blood sampling according to the scheduled time scale, aged between 16 and 65 years) standardised neurological examinations and qualitative and quantitative evaluationof CT were performed. Comprehensive neuropsychological assessment was performed in 39 subjects 2 weeks after admission and in 29 subjects at a 6 month follow up examination. Results-Most patients presented with minor head injuries (GCS greater thanor equal to 3) at the time of admission. Six months later most patients were fully independent in activities of daily living. Two thirds of the patients, however, still had neuropsychological dysfunction. Patients with shortand long term neuropsychological disorders had significantly higher NSE and S-100B serum concentrations and a significantly longer lasting release ofboth markers. A comparative analysis of the predictive value of clinical, neuroradiological, and biochemical data showed initial S-100B values above 140 ng/l to have the highest predictive power. Conclusions-The analysis of posttraumatic release patterns of neurobiochemical markers of brain damage might help to identify patients with traumaticbrain injury who run a risk of long term neuropsychological dysfunction.

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Documento generato il 09/04/20 alle ore 10:53:04